Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4709998..4710514 Replicon chromosome
Accession NZ_CP015120
Organism Klebsiella pneumoniae strain kp757

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag A4U70_RS23385 Protein ID WP_004178374.1
Coordinates 4709998..4710282 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag A4U70_RS23390 Protein ID WP_002886901.1
Coordinates 4710272..4710514 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U70_RS23365 4705481..4705789 - 309 WP_004210629.1 PTS sugar transporter subunit IIB -
A4U70_RS27515 4705874..4706047 + 174 WP_004210630.1 hypothetical protein -
A4U70_RS23370 4706050..4706793 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
A4U70_RS23375 4707150..4709288 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
A4U70_RS23380 4709530..4709994 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
A4U70_RS23385 4709998..4710282 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4U70_RS23390 4710272..4710514 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A4U70_RS23395 4710592..4712502 - 1911 WP_085787720.1 BglG family transcription antiterminator -
A4U70_RS23400 4712525..4713679 - 1155 WP_004210635.1 lactonase family protein -
A4U70_RS23405 4713746..4714486 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T62401 WP_004178374.1 NZ_CP015120:c4710282-4709998 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T62401 NZ_CP015120:c4710282-4709998 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT62401 WP_002886901.1 NZ_CP015120:c4710514-4710272 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT62401 NZ_CP015120:c4710514-4710272 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References