Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1962710..1963299 Replicon chromosome
Accession NZ_CP015115
Organism Ralstonia solanacearum strain EP1

Toxin (Protein)


Gene name hicA Uniprot ID A0A1U9VH68
Locus tag AC251_RS09410 Protein ID WP_072633588.1
Coordinates 1963045..1963299 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1U9VFS6
Locus tag AC251_RS09405 Protein ID WP_028853154.1
Coordinates 1962710..1963048 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AC251_RS09375 1959052..1959390 + 339 WP_072633583.1 phage tail protein -
AC251_RS09380 1959387..1960022 + 636 WP_072633584.1 phage tail protein -
AC251_RS09385 1960028..1960624 + 597 WP_072633585.1 tail fiber assembly protein -
AC251_RS09390 1960621..1961322 + 702 WP_072633586.1 phage minor tail protein L -
AC251_RS09395 1961324..1962034 + 711 WP_072633587.1 C40 family peptidase -
AC251_RS09400 1962038..1962640 + 603 WP_072633645.1 tail assembly protein -
AC251_RS09405 1962710..1963048 - 339 WP_028853154.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AC251_RS09410 1963045..1963299 - 255 WP_072633588.1 type II toxin-antitoxin system HicA family toxin Toxin
AC251_RS09415 1963350..1966505 + 3156 WP_072633589.1 host specificity protein J -
AC251_RS09425 1966842..1967498 + 657 WP_072633591.1 hypothetical protein -
AC251_RS09430 1967567..1968058 + 492 WP_011001641.1 glycoside hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1932755..1980765 48010


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9488.05 Da        Isoelectric Point: 10.3121

>T62374 WP_072633588.1 NZ_CP015115:c1963299-1963045 [Ralstonia solanacearum]
MKAKHQKTLELIFSRPTPAGVKWADAVTLMRELGAELEEREGSRVAVFLFGQVKVMHRPHPSPDMDKGAVASMRKWFEEN
GVKP

Download         Length: 255 bp

>T62374 NZ_CP015115:c1963299-1963045 [Ralstonia solanacearum]
ATGAAAGCCAAACACCAGAAGACGCTGGAGCTGATCTTTTCCCGCCCTACGCCAGCGGGCGTTAAGTGGGCCGATGCCGT
CACGCTCATGCGAGAACTGGGCGCGGAATTGGAGGAGCGCGAGGGTTCTCGCGTGGCCGTCTTCCTGTTTGGTCAAGTTA
AAGTGATGCATCGACCACACCCATCTCCCGATATGGACAAGGGCGCTGTGGCCTCGATGCGTAAGTGGTTCGAGGAAAAC
GGAGTCAAGCCATGA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 11968.58 Da        Isoelectric Point: 5.1375

>AT62374 WP_028853154.1 NZ_CP015115:c1963048-1962710 [Ralstonia solanacearum]
MINVMNIGGHKAVIAYDPDIEMFRGEFVGLNGGADFYAADVTGLHREGELSLRVFLEECARRGVEPQKHFSGKFVLRVEG
KVHEAAAIAAAAQGVSLNQWAAGVLEQAAEAA

Download         Length: 339 bp

>AT62374 NZ_CP015115:c1963048-1962710 [Ralstonia solanacearum]
ATGATCAACGTCATGAACATCGGCGGCCACAAGGCCGTCATCGCCTACGACCCGGATATCGAAATGTTCCGTGGCGAGTT
TGTTGGCCTGAACGGTGGCGCCGATTTCTACGCCGCCGATGTGACCGGCCTGCACCGCGAAGGTGAGTTGTCGCTGCGCG
TGTTTCTGGAAGAGTGCGCACGGCGTGGCGTTGAGCCGCAAAAGCACTTTTCCGGCAAGTTCGTGCTGCGCGTGGAGGGC
AAGGTGCACGAGGCCGCCGCCATCGCCGCTGCCGCGCAAGGCGTGAGCCTTAACCAGTGGGCAGCCGGCGTGCTGGAGCA
AGCCGCCGAGGCGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VH68

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9VFS6

References