Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2545716..2546227 Replicon chromosome
Accession NZ_CP015114
Organism Staphylococcus condimenti strain DSM 11674

Toxin (Protein)


Gene name TsdT Uniprot ID A0A143PEZ9
Locus tag A4G25_RS12235 Protein ID WP_047132367.1
Coordinates 2546021..2546227 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag A4G25_RS12230 Protein ID WP_015900833.1
Coordinates 2545716..2546009 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4G25_RS12205 2541083..2541721 + 639 WP_047132363.1 thiamine phosphate synthase -
A4G25_RS12210 2541810..2542685 + 876 WP_047132364.1 membrane protein insertase YidC -
A4G25_RS12215 2542796..2543308 + 513 WP_047132365.1 GNAT family N-acetyltransferase -
A4G25_RS12220 2543399..2544046 - 648 WP_047132366.1 HD domain-containing protein -
A4G25_RS12225 2544071..2545551 - 1481 Protein_2396 cardiolipin synthase -
A4G25_RS12230 2545716..2546009 + 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
A4G25_RS12235 2546021..2546227 + 207 WP_047132367.1 cation transporter Toxin
A4G25_RS12240 2546242..2546451 + 210 WP_047132368.1 copper ion binding protein -
A4G25_RS12245 2546548..2548749 + 2202 WP_047132369.1 heavy metal translocating P-type ATPase -
A4G25_RS13120 2548825..2548965 + 141 WP_165380001.1 hypothetical protein -
A4G25_RS12250 2549045..2550256 - 1212 WP_047132370.1 rod shape-determining protein RodA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7815.73 Da        Isoelectric Point: 4.1353

>T62371 WP_047132367.1 NZ_CP015114:2546021-2546227 [Staphylococcus condimenti]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVTAVQVDLDSNEIKISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T62371 NZ_CP015114:2546021-2546227 [Staphylococcus condimenti]
ATGCAAAACAGTGTAATTAAAATTGATGGAATGGAAACTGAAGAAGAACAGCATAAATTACATCAACATCTTATAGAAAT
GACAGGTGTAACTGCAGTACAAGTAGATTTGGATTCAAATGAAATCAAAATCAGTTACGAAACACCTGTAAATCTCAATA
ATCTTGAAAAAGAAATCTATGATGCGGGTTATCAAATATTAAATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT62371 WP_015900833.1 NZ_CP015114:2545716-2546009 [Staphylococcus condimenti]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT62371 NZ_CP015114:2545716-2546009 [Staphylococcus condimenti]
ATGACCGAAAATGACAAAGCACATCATTCAGAACAAATTAAGTCCAACTTGAAAGCAAGACTCAACCGTATTGAGGGGCA
AGTCAGAGCAATTAACCGAATGATTGAAGAAGATGTTTATTGTGATGATGTACTTACACAAATCCGTGCAACACGTTCAG
CCTTGAACAGTGTAGCAGTACGATTGCTTGATCACCATATGAAAGGTTGTATCATGCATAAAGTTGAGGATGGTCACGCT
GAAGAAGCAATGGAAGAATTGCTTGTTACCGTTCAAAAATTAATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143PEZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References