Detailed information of TA system TA062369

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3888129..3888846
• Replicon: chromosome
• Accession: NZ_CP015113
• Organism: Kosakonia radicincitans strain GXGL-4A

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: A3780_RS18235
• Protein ID: WP_156897441.1
• Coordinates: 3888544..3888846 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: A3780_RS18230
• Protein ID: WP_071921228.1
• Coordinates: 3888129..3888488 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A3780_RS18180	3883837..3884562	+	726	WP_071921221.1	DUF3944 domain-containing protein	-
A3780_RS18185	3884622..3885299	+	678	WP_071921222.1	WYL domain-containing protein	-
A3780_RS18190	3885407..3885817	+	411	WP_071921877.1	hypothetical protein	-
A3780_RS18195	3885872..3886231	+	360	WP_071921223.1	hypothetical protein	-
A3780_RS18200	3886312..3886524	+	213	WP_071921224.1	hypothetical protein	-
A3780_RS18205	3886635..3887057	+	423	Protein_3554	DUF932 domain-containing protein	-
A3780_RS18210	3887032..3887148	+	117	Protein_3555	antirestriction protein	-
A3780_RS18215	3887159..3887392	+	234	WP_071921225.1	hypothetical protein	-
A3780_RS18220	3887389..3887871	+	483	WP_071921226.1	DNA repair protein RadC	-
A3780_RS18225	3887885..3888106	+	222	WP_071921227.1	DUF987 domain-containing protein	-
A3780_RS18230	3888129..3888488	+	360	WP_071921228.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
A3780_RS18235	3888544..3888846	+	303	WP_156897441.1	TA system toxin CbtA family protein	Toxin
A3780_RS18240	3888814..3889491	-	678	Protein_3561	glycosyltransferase	-
A3780_RS18245	3890513..3892633	-	2121	WP_064277560.1	DUF87 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3872868..3897156	24288

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (7-97)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11272.83 Da
• Isoelectric Point: 5.5647

>T62369 WP_156897441.1 NZ_CP015113:3888544-3888846 [Kosakonia radicincitans]
IQSLPPQRAASSRLSSVEIWQKLLEYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGFSV
KEQYPFIGSIDIVIIRAVGN

Nucleotide

• Length: 303 bp

>T62369 NZ_CP015113:3888544-3888846 [Kosakonia radicincitans]
ATACAATCCCTGCCCCCTCAAAGGGCGGCATCGTCACGTCTGTCATCAGTCGAAATCTGGCAAAAATTACTGGAGTATCT
GCTGGAGCAACACTACGGCCTTACCCTCAACGACACGCCGTTTGGCAACGACAGTGTGATCCAGAAGCACATTGATGCGG
GTATCTCACTGTGTGACGCGGTAAATTTTATCGTGGAAAAGTACGACCTGGTGCGTACTGACCGTCACGGCTTCAGCGTG
AAAGAGCAGTATCCGTTTATCGGCAGCATTGATATCGTAATAATCCGGGCGGTGGGTAATTGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13305.46 Da
• Isoelectric Point: 7.7514

>AT62369 WP_071921228.1 NZ_CP015113:3888129-3888488 [Kosakonia radicincitans]
MQKATRVINHNIAEPWWGLRRNITPCLGARLVQEGNRLHYLADRASIAGTFNDADLRHLDQAFPVLMKQMELMLASSELT
PHIQRCITLHAKGLICEADTLGSCGYLYIVIYPTSAITA

Nucleotide

• Length: 360 bp

>AT62369 NZ_CP015113:3888129-3888488 [Kosakonia radicincitans]
ATGCAGAAAGCAACCCGTGTAATCAACCATAATATCGCGGAACCCTGGTGGGGCCTCAGACGCAACATCACGCCGTGTTT
GGGTGCCCGGCTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCTGACCGCGCCAGCATTGCCGGGACATTTAATGACG
CAGATTTACGCCATCTGGACCAGGCATTTCCGGTACTGATGAAGCAGATGGAGCTTATGCTGGCCAGCAGCGAACTCACG
CCCCACATTCAGCGCTGCATCACGCTCCACGCAAAAGGGCTGATATGTGAGGCTGATACGCTCGGCTCCTGTGGCTATTT
GTATATCGTAATTTATCCGACATCTGCAATAACCGCATAA