Detailed information of TA system TA062357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RHH
• Location: 1326514..1327071
• Replicon: chromosome
• Accession: NZ_CP015113
• Organism: Kosakonia radicincitans strain GXGL-4A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6M5D0S3
• Locus tag: A3780_RS06165
• Protein ID: WP_007373777.1
• Coordinates: 1326514..1326789 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: A3780_RS06170
• Protein ID: WP_071920458.1
• Coordinates: 1326793..1327071 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A3780_RS06140	1322045..1322458	+	414	WP_035886032.1	proofreading thioesterase EntH	-
A3780_RS06145	1322626..1324731	+	2106	WP_035886031.1	carbon starvation protein CstA	-
A3780_RS06150	1324780..1324977	+	198	WP_000460621.1	YbdD/YjiX family protein	-
A3780_RS06155	1324997..1325740	-	744	WP_071920456.1	3-oxoacyl-ACP reductase FabG	-
A3780_RS06160	1325852..1326439	+	588	WP_071920457.1	TetR/AcrR family transcriptional regulator	-
A3780_RS06165	1326514..1326789	-	276	WP_007373777.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
A3780_RS06170	1326793..1327071	-	279	WP_071920458.1	CopG family ribbon-helix-helix protein	Antitoxin
A3780_RS06175	1327359..1328447	-	1089	WP_071920459.1	oxidoreductase	-
A3780_RS06180	1328610..1330112	+	1503	WP_071920460.1	sugar ABC transporter ATP-binding protein	-
A3780_RS06185	1330109..1331104	+	996	WP_007373782.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10835.61 Da
• Isoelectric Point: 5.1100

>T62357 WP_007373777.1 NZ_CP015113:c1326789-1326514 [Kosakonia radicincitans]
MQLEWTRLALQDVERLSKFLFIQNPEAARKVVIMLADAPEMLLLHPQIGPPDESWYPREVRSLFVGSYEMIYELTDSHII
ILRIWHTKEDR

Nucleotide

• Length: 276 bp

>T62357 NZ_CP015113:c1326789-1326514 [Kosakonia radicincitans]
ATGCAGTTAGAATGGACGCGACTCGCTCTTCAGGATGTAGAGAGACTGTCAAAATTCCTGTTTATCCAAAACCCTGAAGC
CGCCCGCAAAGTTGTCATCATGTTGGCTGACGCCCCTGAAATGCTCTTGCTCCACCCACAAATAGGCCCGCCGGATGAAA
GCTGGTATCCGCGCGAAGTCCGTTCTTTGTTTGTTGGCAGTTATGAAATGATTTACGAACTGACGGACAGCCATATCATC
ATCCTGCGAATCTGGCATACAAAAGAAGACCGTTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10078.65 Da
• Isoelectric Point: 8.6586

>AT62357 WP_071920458.1 NZ_CP015113:c1327071-1326793 [Kosakonia radicincitans]
MSGTKVLTAHVPIELADKVDLLAESSERSRGWIIKRALAEYIERAELRQAMIQQGLDAVERGETVSHAEAATWLKSLGTV
NPMPLPGVKKRG

Nucleotide

• Length: 279 bp

>AT62357 NZ_CP015113:c1327071-1326793 [Kosakonia radicincitans]
ATGTCTGGGACGAAAGTACTGACAGCGCATGTACCTATTGAACTCGCCGATAAAGTCGATTTACTTGCCGAAAGCAGCGA
ACGCTCGCGGGGCTGGATTATCAAGCGTGCGCTCGCGGAATATATTGAGCGTGCAGAATTACGCCAGGCCATGATCCAGC
AAGGCCTGGATGCCGTTGAACGCGGTGAAACTGTCAGTCATGCAGAAGCGGCAACCTGGCTTAAAAGTCTGGGGACGGTT
AATCCAATGCCGCTGCCAGGCGTTAAAAAACGGGGATGA

Structures

Toxin

• AlphaFold DB: A0A6M5D0S3