Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1049069..1049685 Replicon chromosome
Accession NZ_CP015113
Organism Kosakonia radicincitans strain GXGL-4A

Toxin (Protein)


Gene name Hha Uniprot ID A0A1C4FBY4
Locus tag A3780_RS04915 Protein ID WP_007373583.1
Coordinates 1049069..1049287 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6M5CWA9
Locus tag A3780_RS04920 Protein ID WP_007373584.1
Coordinates 1049311..1049685 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3780_RS04885 1045252..1045512 + 261 WP_007373576.1 type B 50S ribosomal protein L31 -
A3780_RS04890 1045516..1045656 + 141 WP_007373577.1 type B 50S ribosomal protein L36 -
A3780_RS04895 1045653..1046354 - 702 WP_035887312.1 GNAT family N-acetyltransferase -
A3780_RS04900 1046452..1047897 + 1446 WP_007373580.1 PLP-dependent aminotransferase family protein -
A3780_RS04905 1047863..1048342 - 480 WP_035887316.1 YlaC family protein -
A3780_RS04910 1048443..1049003 - 561 WP_007373582.1 maltose O-acetyltransferase -
A3780_RS04915 1049069..1049287 - 219 WP_007373583.1 hemolysin expression modulator Hha Toxin
A3780_RS04920 1049311..1049685 - 375 WP_007373584.1 Hha toxicity modulator TomB Antitoxin
A3780_RS04925 1050199..1053348 - 3150 WP_007373585.1 multidrug efflux RND transporter permease subunit -
A3780_RS04930 1053371..1054564 - 1194 WP_007373586.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8637.05 Da        Isoelectric Point: 7.9893

>T62356 WP_007373583.1 NZ_CP015113:c1049287-1049069 [Kosakonia radicincitans]
MSEKPLTKVDYLMRLRRCQTIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T62356 NZ_CP015113:c1049287-1049069 [Kosakonia radicincitans]
ATGTCCGAAAAACCATTAACAAAAGTTGATTATTTGATGCGTCTCAGACGTTGTCAGACAATTGATACCCTTGAACGTGT
AATTGAAAAAAATAAATACGAACTTCCGGATGAGGAACTCGCGGTGTTTTATTCAGCAGCCGATCATCGCCTGGCAGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCCTCCTCCGTGTGGAAATTTGTACGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14567.42 Da        Isoelectric Point: 5.8339

>AT62356 WP_007373584.1 NZ_CP015113:c1049685-1049311 [Kosakonia radicincitans]
MDEYSPKRHDIAQLKFLCETLYHDCLVNLEESHHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTHDLQKWRKTGNKLFRCFVNVSKANPVSHSC

Download         Length: 375 bp

>AT62356 NZ_CP015113:c1049685-1049311 [Kosakonia radicincitans]
ATGGACGAATACTCGCCAAAAAGGCATGATATCGCGCAGCTCAAATTTCTCTGCGAAACACTGTACCATGACTGCCTTGT
TAATCTCGAAGAGAGCCATCATGGGTGGGTTAACGATCCTACATCAGCGGTGAACTTGCAGTTAAATGAGCTGATAGAAC
ACATAGCGACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAACTGATTGAACAGATAGACGAATATCTT
GACGATACGTTTATGTTGTTCAGTAGCTATGGCATAAATACACATGACTTACAGAAATGGCGCAAAACAGGTAACAAGCT
GTTCCGCTGCTTCGTCAATGTAAGCAAGGCTAATCCTGTTAGCCACTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C4FBY4

Antitoxin

Source ID Structure
AlphaFold DB A0A6M5CWA9

References