Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 421677..422322 Replicon chromosome
Accession NZ_CP015113
Organism Kosakonia radicincitans strain GXGL-4A

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag A3780_RS01940 Protein ID WP_035886605.1
Coordinates 422140..422322 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A3780_RS01935 Protein ID WP_035943124.1
Coordinates 421677..422114 (-) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3780_RS01910 416920..417744 + 825 WP_071920160.1 ABC transporter ATP-binding protein -
A3780_RS01915 417741..418763 + 1023 WP_071920161.1 iron ABC transporter permease -
A3780_RS01920 418760..419812 + 1053 WP_035886609.1 iron ABC transporter permease -
A3780_RS01925 419827..420774 + 948 WP_071920162.1 iron-siderophore ABC transporter substrate-binding protein -
A3780_RS01930 420787..421680 + 894 WP_071920163.1 MurR/RpiR family transcriptional regulator -
A3780_RS01935 421677..422114 - 438 WP_035943124.1 hypothetical protein Antitoxin
A3780_RS01940 422140..422322 - 183 WP_035886605.1 type II toxin-antitoxin system HicA family toxin Toxin
A3780_RS01945 422393..423559 - 1167 WP_071920164.1 multidrug effflux MFS transporter -
A3780_RS01950 423626..424198 - 573 WP_007372977.1 TetR/AcrR family transcriptional regulator -
A3780_RS01955 424390..425175 - 786 WP_071920165.1 NAD(P)H-dependent oxidoreductase -
A3780_RS01960 425262..426167 + 906 WP_071920166.1 LysR family transcriptional regulator -
A3780_RS01965 426295..427248 + 954 WP_007372980.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6770.97 Da        Isoelectric Point: 11.0174

>T62354 WP_035886605.1 NZ_CP015113:c422322-422140 [Kosakonia radicincitans]
MKYSEFRKWLLSQGAELTKAPGGGSHFKVRLNGRASVFPFHGSKEIPEPLRKKIMKDLGL

Download         Length: 183 bp

>T62354 NZ_CP015113:c422322-422140 [Kosakonia radicincitans]
ATGAAATACAGCGAGTTCAGAAAGTGGTTGTTATCTCAGGGAGCGGAGCTAACCAAAGCTCCAGGTGGAGGAAGCCATTT
TAAAGTCAGGCTTAATGGTAGGGCATCGGTTTTCCCTTTTCATGGTTCGAAAGAGATTCCTGAGCCGTTGAGGAAAAAGA
TTATGAAGGACTTAGGCCTGTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 15953.41 Da        Isoelectric Point: 5.5739

>AT62354 WP_035943124.1 NZ_CP015113:c422114-421677 [Kosakonia radicincitans]
MFNYPVHIERDDATGQFVVSCRDLPLMNSVGDTLDEALLQSIDGIVVAIAIEIDERRPIPAASAPLKGEYIVSLPVLVAM
KAALHNAMIETGTRKAELARKLGQKGPQIDRLLDVEHSSKVETVELALHQLNRQIDLTITPQHRA

Download         Length: 438 bp

>AT62354 NZ_CP015113:c422114-421677 [Kosakonia radicincitans]
ATGTTTAATTATCCCGTCCACATTGAACGAGACGATGCTACAGGTCAGTTCGTGGTCTCATGCCGCGATCTACCGCTCAT
GAACTCCGTTGGCGATACGCTTGATGAGGCTTTACTGCAGTCGATTGATGGGATTGTTGTTGCGATTGCTATCGAAATTG
ACGAGCGGCGTCCAATCCCGGCGGCAAGCGCGCCGCTAAAAGGCGAATACATCGTATCGCTGCCCGTACTCGTAGCCATG
AAAGCCGCACTGCATAACGCCATGATCGAAACCGGGACGCGAAAAGCTGAGCTGGCAAGAAAGCTGGGACAGAAAGGGCC
GCAAATTGACCGCTTGCTCGATGTGGAGCACTCATCGAAGGTGGAAACGGTTGAACTGGCGCTACATCAGTTAAATCGAC
AGATTGATCTGACCATTACGCCGCAGCACAGAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References