Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1175816..1176405 Replicon chromosome
Accession NZ_CP015110
Organism Acinetobacter sp. TGL-Y2

Toxin (Protein)


Gene name relE Uniprot ID A0A143G2H9
Locus tag AMD27_RS05470 Protein ID WP_067657406.1
Coordinates 1175816..1176112 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A143G3R9
Locus tag AMD27_RS05475 Protein ID WP_067657409.1
Coordinates 1176115..1176405 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AMD27_RS05435 1171143..1171496 - 354 WP_067657399.1 hypothetical protein -
AMD27_RS05440 1171496..1172743 - 1248 WP_067657402.1 hypothetical protein -
AMD27_RS05445 1173125..1173499 + 375 WP_067655598.1 IS630 transposase-related protein -
AMD27_RS18025 1173496..1174044 + 549 WP_081405914.1 IS630 family transposase -
AMD27_RS05455 1174148..1174612 - 465 WP_067656583.1 IS1 family transposase -
AMD27_RS05460 1174605..1174886 - 282 WP_067657355.1 hypothetical protein -
AMD27_RS05465 1175007..1175705 + 699 WP_067657404.1 hypothetical protein -
AMD27_RS05470 1175816..1176112 + 297 WP_067657406.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AMD27_RS05475 1176115..1176405 + 291 WP_067657409.1 putative addiction module antidote protein Antitoxin
AMD27_RS05480 1176491..1177039 - 549 WP_067657412.1 cysteine hydrolase -
AMD27_RS05485 1177123..1178007 - 885 WP_067657415.1 MBL fold metallo-hydrolase -
AMD27_RS05490 1178140..1179117 + 978 WP_067657418.1 helix-turn-helix domain-containing protein -
AMD27_RS05495 1179458..1180078 + 621 WP_067662796.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1108637..1266332 157695
- flank IS/Tn - - 1170032..1170964 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(7-93)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11443.18 Da        Isoelectric Point: 8.0035

>T62351 WP_067657406.1 NZ_CP015110:1175816-1176112 [Acinetobacter sp. TGL-Y2]
MIEIKRLPEFDEWLDDIKGNMTRIRLNRRLDKVQRGNWGDIKPLQEGVWEMRGFFGSGCRMYYIQHGDVVIVMLGGGDKS
TQQDDIKRAVKLSKTLED

Download         Length: 297 bp

>T62351 NZ_CP015110:1175816-1176112 [Acinetobacter sp. TGL-Y2]
ATGATTGAAATTAAACGTCTGCCTGAATTTGATGAATGGTTAGATGACATTAAAGGCAATATGACCCGTATTCGCCTGAA
TCGTCGATTAGATAAGGTTCAGCGTGGAAATTGGGGAGACATTAAACCTCTCCAAGAAGGTGTATGGGAAATGAGAGGGT
TCTTCGGTTCCGGTTGCAGAATGTACTATATCCAACATGGTGATGTTGTGATTGTGATGCTAGGTGGCGGTGATAAATCT
ACACAGCAAGACGATATCAAGCGAGCAGTTAAATTATCTAAAACATTGGAGGATTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10496.07 Da        Isoelectric Point: 5.1007

>AT62351 WP_067657409.1 NZ_CP015110:1176115-1176405 [Acinetobacter sp. TGL-Y2]
MVKVADLPSFDMTESLKTEEDIVTYLNMVLEDNDPAELAHALGVIAKARGMTQIAKEAGIGREALYKALRHDSAPRFDTI
NRVVNALGLKLTVQNA

Download         Length: 291 bp

>AT62351 NZ_CP015110:1176115-1176405 [Acinetobacter sp. TGL-Y2]
ATGGTTAAAGTCGCTGATTTACCAAGTTTTGATATGACTGAATCACTTAAAACTGAAGAAGATATTGTGACGTATCTCAA
TATGGTTCTTGAAGATAATGATCCTGCTGAATTAGCTCATGCGCTTGGTGTAATTGCTAAAGCAAGAGGGATGACCCAGA
TTGCAAAAGAGGCAGGTATTGGCCGTGAAGCTCTTTACAAAGCACTTCGTCATGACTCTGCACCTCGTTTTGATACGATC
AATCGTGTAGTGAATGCTTTAGGTTTAAAACTTACAGTTCAAAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143G2H9

Antitoxin

Source ID Structure
AlphaFold DB A0A143G3R9

References