Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1073809..1074412 Replicon chromosome
Accession NZ_CP015106
Organism Thermococcus radiotolerans strain EJ2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A3L10_RS05935 Protein ID WP_088866784.1
Coordinates 1073809..1074201 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A3L10_RS05940 Protein ID WP_088866785.1
Coordinates 1074188..1074412 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3L10_RS05905 (A3L10_05895) 1069286..1070755 - 1470 WP_088866778.1 S-layer protein -
A3L10_RS05910 (A3L10_05900) 1070820..1071359 + 540 WP_232460949.1 DUF2391 family protein -
A3L10_RS05915 (A3L10_05905) 1071360..1072391 + 1032 WP_088866780.1 DUF3226 domain-containing protein -
A3L10_RS05920 (A3L10_05910) 1072431..1073126 + 696 WP_088866781.1 HAD family hydrolase -
A3L10_RS05925 (A3L10_05915) 1073123..1073563 - 441 WP_232460950.1 type II toxin-antitoxin system VapC family toxin -
A3L10_RS05930 (A3L10_05920) 1073553..1073750 - 198 WP_232460951.1 hypothetical protein -
A3L10_RS05935 (A3L10_05925) 1073809..1074201 - 393 WP_088866784.1 type II toxin-antitoxin system VapC family toxin Toxin
A3L10_RS05940 (A3L10_05930) 1074188..1074412 - 225 WP_088866785.1 hypothetical protein Antitoxin
A3L10_RS05945 (A3L10_05935) 1074470..1076797 - 2328 WP_088866786.1 DNA polymerase -
A3L10_RS05950 (A3L10_05940) 1076879..1077433 - 555 WP_088866787.1 hypothetical protein -
A3L10_RS05955 (A3L10_05945) 1077537..1078898 + 1362 WP_088867549.1 RsmB/NOP family class I SAM-dependent RNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin

Putative antitoxin VapB3-like

(1-74)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14472.72 Da        Isoelectric Point: 4.1960

>T62349 WP_088866784.1 NZ_CP015106:c1074201-1073809 [Thermococcus radiotolerans]
VIVVDASVLVKVLLKEPGWEEIELDSSTATLDYAFVEGMNAIWKAIRRGRATEEAGRNLITVLKLIGEGMLTFEAQNFFE
RGLEIALGENITIYDALYIALAEVLNAEFLTADEKQYLAAKNYVKAMLVE

Download         Length: 393 bp

>T62349 NZ_CP015106:c1074201-1073809 [Thermococcus radiotolerans]
GTGATAGTCGTTGATGCCTCGGTTCTCGTCAAGGTTCTCCTCAAGGAACCAGGCTGGGAGGAGATTGAGCTCGATTCCAG
CACGGCGACGCTGGACTATGCCTTCGTTGAAGGAATGAATGCTATATGGAAAGCCATTAGGAGGGGTAGAGCCACCGAAG
AGGCCGGCAGGAACCTTATAACCGTCCTCAAACTCATCGGGGAGGGTATGCTCACGTTTGAGGCGCAAAACTTCTTCGAG
AGGGGGCTGGAAATAGCATTGGGGGAGAACATCACGATCTACGATGCCCTTTACATAGCCCTGGCCGAGGTACTGAACGC
GGAATTTCTGACTGCGGACGAGAAACAGTATCTGGCCGCCAAAAACTACGTCAAGGCGATGCTCGTTGAATAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8913.38 Da        Isoelectric Point: 10.4766

>AT62349 WP_088866785.1 NZ_CP015106:c1074412-1074188 [Thermococcus radiotolerans]
MAIVTVRVPDELKLKMKELNVNWSEEIREFIRRRIDEEERRKKIKEAMEILKRTPVSVEKGFAAKSVREDRDSR

Download         Length: 225 bp

>AT62349 NZ_CP015106:c1074412-1074188 [Thermococcus radiotolerans]
ATGGCCATTGTTACTGTCCGCGTTCCCGATGAGTTGAAGCTCAAGATGAAGGAGCTTAACGTAAACTGGAGCGAGGAGAT
TAGAGAGTTCATAAGAAGGCGCATAGACGAGGAAGAACGGAGAAAGAAGATAAAAGAGGCCATGGAGATACTCAAACGCA
CACCGGTTTCTGTCGAGAAGGGGTTTGCAGCGAAGTCCGTGAGGGAGGACCGTGATAGTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References