Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1365813..1366501 Replicon chromosome
Accession NZ_CP015105
Organism Thermococcus thioreducens strain OGL-20P

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A3L14_RS07580 Protein ID WP_055429448.1
Coordinates 1366094..1366501 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A3L14_RS07575 Protein ID WP_232473299.1
Coordinates 1365813..1366097 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3L14_RS07545 (A3L14_07515) 1361455..1363185 + 1731 WP_055429443.1 carbon starvation protein A -
A3L14_RS07550 (A3L14_07520) 1363222..1363509 + 288 WP_055429444.1 hypothetical protein -
A3L14_RS07555 (A3L14_07525) 1363521..1363802 + 282 WP_198300086.1 hypothetical protein -
A3L14_RS07560 (A3L14_07530) 1363812..1364804 + 993 WP_055429445.1 ArsA family ATPase -
A3L14_RS07565 (A3L14_07535) 1364794..1365096 + 303 WP_074631168.1 iron-sulfur cluster assembly protein -
A3L14_RS07570 (A3L14_07540) 1365101..1365757 + 657 WP_055429446.1 hypothetical protein -
A3L14_RS07575 (A3L14_07545) 1365813..1366097 + 285 WP_232473299.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A3L14_RS07580 (A3L14_07550) 1366094..1366501 + 408 WP_055429448.1 type II toxin-antitoxin system VapC family toxin Toxin
A3L14_RS07585 (A3L14_07555) 1366503..1367294 + 792 WP_055429449.1 alpha/beta hydrolase -
A3L14_RS07590 (A3L14_07560) 1367287..1368306 - 1020 WP_074631167.1 adenylosuccinate synthetase -
A3L14_RS07595 (A3L14_07565) 1368439..1369371 + 933 WP_055429450.1 SDR family oxidoreductase -
A3L14_RS07600 (A3L14_07570) 1369346..1371076 - 1731 WP_083391968.1 DUF2341 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(10-52)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15547.80 Da        Isoelectric Point: 4.3293

>T62348 WP_055429448.1 NZ_CP015105:1366094-1366501 [Thermococcus thioreducens]
MKLFIDTNLFVYLNSRIPEEIADKLDEFYANLTQNHELYTDVLVLDELIHVSRRKYGIAQGDTIEFIDDIILPAVRVLPL
TFQDYLTAKGIIRQYNLRPSDALHVAVIENNGLQTIVSEDEDFDVLPLKRLWLGG

Download         Length: 408 bp

>T62348 NZ_CP015105:1366094-1366501 [Thermococcus thioreducens]
ATGAAACTCTTCATAGACACGAACCTCTTCGTTTATCTTAACTCAAGGATTCCAGAAGAAATCGCTGACAAACTAGATGA
ATTCTACGCCAACCTCACCCAGAATCATGAACTTTACACTGATGTGCTGGTTCTCGATGAGCTGATCCACGTTTCAAGGC
GTAAGTATGGGATAGCCCAGGGAGACACAATAGAGTTCATAGATGACATTATCCTGCCGGCGGTTCGGGTTCTTCCGTTG
ACGTTCCAGGACTACTTAACTGCCAAGGGGATAATCCGCCAGTACAACCTCCGTCCCTCCGATGCCCTTCACGTTGCAGT
CATAGAGAACAACGGCCTCCAGACCATAGTCAGCGAGGATGAAGACTTCGACGTTCTTCCACTGAAAAGGCTCTGGCTGG
GTGGTTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10603.42 Da        Isoelectric Point: 7.0198

>AT62348 WP_232473299.1 NZ_CP015105:1365813-1366097 [Thermococcus thioreducens]
VIPLVSIRLKVGPKGQIVIPKVFREAYGIKEGGEVIVEPTEDGLVIKKPPNKEELLRKLKEYHEKRKGTKPAKLGELKGI
SLEDEFDEVWGIEE

Download         Length: 285 bp

>AT62348 NZ_CP015105:1365813-1366097 [Thermococcus thioreducens]
GTGATACCGTTGGTTAGCATACGCCTTAAGGTCGGCCCGAAGGGACAGATAGTCATCCCCAAAGTTTTCCGTGAGGCTTA
CGGCATAAAGGAGGGCGGAGAGGTAATAGTCGAACCGACGGAAGATGGTCTCGTTATAAAAAAGCCCCCAAATAAGGAGG
AACTGCTCAGAAAGCTTAAGGAGTATCACGAAAAGAGGAAGGGGACGAAACCTGCCAAACTTGGAGAGCTTAAGGGGATA
AGCCTCGAAGACGAGTTCGACGAGGTCTGGGGGATTGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References