Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1475042..1475648 Replicon chromosome
Accession NZ_CP015103
Organism Thermococcus siculi strain RG-20

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A3L11_RS07965 Protein ID WP_232461977.1
Coordinates 1475244..1475648 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A3L11_RS07960 Protein ID WP_088856401.1
Coordinates 1475042..1475263 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3L11_RS07940 (A3L11_07945) 1470643..1472922 - 2280 WP_088856397.1 alpha-amylase family glycosyl hydrolase -
A3L11_RS07945 (A3L11_07950) 1473068..1473298 + 231 WP_088856398.1 LSm family protein -
A3L11_RS07950 (A3L11_07955) 1473319..1473510 + 192 WP_088856399.1 50S ribosomal protein L37e -
A3L11_RS07955 (A3L11_07960) 1473621..1474991 + 1371 WP_088856400.1 MATE family efflux transporter -
A3L11_RS07960 (A3L11_07965) 1475042..1475263 + 222 WP_088856401.1 hypothetical protein Antitoxin
A3L11_RS07965 (A3L11_07970) 1475244..1475648 + 405 WP_232461977.1 type II toxin-antitoxin system VapC family toxin Toxin
A3L11_RS07970 (A3L11_07975) 1475645..1476739 - 1095 WP_088856403.1 VIT1/CCC1 transporter family protein -
A3L11_RS07975 (A3L11_07980) 1476850..1477653 + 804 WP_088856404.1 PIG-L deacetylase family protein -
A3L11_RS07980 (A3L11_07985) 1477645..1478094 - 450 WP_088856405.1 type II toxin-antitoxin system VapC family toxin -
A3L11_RS07985 (A3L11_07990) 1478097..1478306 - 210 WP_088856406.1 hypothetical protein -
A3L11_RS07990 (A3L11_07995) 1478303..1479757 - 1455 WP_088856407.1 beta-galactosidase BgaS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(5-131)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15295.69 Da        Isoelectric Point: 5.2154

>T62347 WP_232461977.1 NZ_CP015103:1475244-1475648 [Thermococcus siculi]
MTVIVIDASLLARYVLLEPGWEDMERFLQNDLVSLEYALVEVSNALWKHHVLYNRISREEFERRCQVVDMLPSVVLFENP
MRYLGNARKIAADRGVTVYDALYIAQALKYGSLATSDKKQGRVAEGLGVDVIYI

Download         Length: 405 bp

>T62347 NZ_CP015103:1475244-1475648 [Thermococcus siculi]
ATGACCGTGATAGTAATTGACGCCTCCCTACTGGCCAGATACGTCCTTCTGGAGCCGGGATGGGAAGATATGGAGAGGTT
TCTCCAGAATGACCTTGTCTCCCTGGAGTACGCTCTGGTGGAAGTTTCAAACGCACTGTGGAAGCACCACGTCCTCTACA
ATCGAATAAGCAGGGAGGAGTTTGAGCGACGCTGTCAGGTCGTGGACATGCTCCCCAGCGTCGTGCTCTTTGAGAATCCA
ATGAGGTATCTGGGAAATGCCAGGAAAATTGCCGCGGATCGGGGAGTGACCGTTTACGATGCCCTCTACATAGCCCAGGC
CCTCAAGTACGGCTCTCTGGCTACAAGCGACAAAAAGCAGGGAAGAGTGGCGGAAGGGCTGGGCGTTGATGTGATTTACA
TCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8529.75 Da        Isoelectric Point: 5.9168

>AT62347 WP_088856401.1 NZ_CP015103:1475042-1475263 [Thermococcus siculi]
MAVISVRIPDELKAKMKELDVNWSEEIRRFIEKKIREEEKEKTLREMHELLAGGTPAEKGTAAKYVRDDRDSN

Download         Length: 222 bp

>AT62347 NZ_CP015103:1475042-1475263 [Thermococcus siculi]
ATGGCGGTTATAAGCGTCCGCATTCCCGACGAACTCAAGGCCAAGATGAAGGAACTCGACGTGAACTGGAGCGAAGAAAT
ACGGAGGTTCATTGAAAAAAAGATCAGGGAAGAAGAGAAGGAGAAAACCCTCCGGGAAATGCACGAACTCCTAGCTGGAG
GCACCCCCGCTGAGAAGGGAACCGCAGCGAAGTACGTGAGGGATGACCGTGATAGTAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References