Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 826331..826934 Replicon chromosome
Accession NZ_CP015103
Organism Thermococcus siculi strain RG-20

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A3L11_RS04375 Protein ID WP_232462040.1
Coordinates 826536..826934 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A3L11_RS04370 Protein ID WP_088855744.1
Coordinates 826331..826555 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3L11_RS04360 (A3L11_04360) 822159..822386 + 228 WP_088855742.1 hypothetical protein -
A3L11_RS04365 (A3L11_04365) 822681..826175 + 3495 WP_088855743.1 DNA polymerase domain-containing protein -
A3L11_RS04370 (A3L11_04370) 826331..826555 + 225 WP_088855744.1 hypothetical protein Antitoxin
A3L11_RS04375 (A3L11_04375) 826536..826934 + 399 WP_232462040.1 type II toxin-antitoxin system VapC family toxin Toxin
A3L11_RS04380 (A3L11_04380) 826938..828317 - 1380 WP_088855746.1 ATP-binding protein -
A3L11_RS04385 (A3L11_04385) 828524..829216 - 693 WP_088855747.1 HAD family hydrolase -
A3L11_RS04390 (A3L11_04390) 829257..830294 - 1038 WP_088855748.1 DUF3226 domain-containing protein -
A3L11_RS04395 (A3L11_04395) 830295..830834 - 540 WP_232462041.1 DUF2391 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Putative antitoxin VapB3-like

(1-74)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14921.43 Da        Isoelectric Point: 6.4834

>T62345 WP_232462040.1 NZ_CP015103:826536-826934 [Thermococcus siculi]
MTVIVIDASVLIKVLLKEPGWEKIALGTDTATLDYALVEGMNAIWKAVKRNRTTEENAKSLVTVLRLLREGMLLFRAENF
FERGLEIALKESITIYDALYIALAEALNAELHTADERQYHAARDYVKAKLIK

Download         Length: 399 bp

>T62345 NZ_CP015103:826536-826934 [Thermococcus siculi]
ATGACCGTGATAGTCATTGATGCATCCGTTCTCATCAAAGTTCTCCTCAAAGAACCCGGCTGGGAAAAAATAGCGCTTGG
CACGGACACGGCAACCCTGGACTACGCGCTCGTCGAAGGGATGAACGCCATCTGGAAGGCCGTCAAAAGAAACAGAACAA
CGGAAGAGAACGCCAAAAGCCTCGTAACGGTTCTGAGGCTTCTCAGGGAGGGGATGCTCCTGTTCCGGGCGGAGAACTTC
TTCGAGCGGGGCCTCGAAATAGCCCTGAAGGAAAGCATCACGATTTACGACGCCCTTTACATAGCCCTGGCTGAAGCCCT
CAACGCGGAACTCCACACGGCGGACGAGAGGCAGTACCATGCCGCCCGAGATTACGTAAAGGCGAAGCTGATAAAGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8894.29 Da        Isoelectric Point: 9.9430

>AT62345 WP_088855744.1 NZ_CP015103:826331-826555 [Thermococcus siculi]
MAIITIRVPDELKLKMRELNINWSEEIREFIRKRIDEEERRKKINEAMEILKRTPVSVEKGFGAKSVRDDRDSH

Download         Length: 225 bp

>AT62345 NZ_CP015103:826331-826555 [Thermococcus siculi]
ATGGCGATCATAACCATTAGGGTTCCCGACGAGCTGAAGCTCAAGATGCGGGAGCTTAACATAAACTGGAGCGAGGAGAT
AAGGGAGTTCATACGAAAGAGGATAGACGAGGAGGAGCGGAGAAAAAAGATAAATGAGGCAATGGAAATACTGAAGCGCA
CGCCCGTCTCGGTTGAAAAGGGCTTTGGGGCGAAATCCGTGAGGGATGACCGTGATAGTCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References