Detailed information of TA system TA062342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2026685..2027462
• Replicon: chromosome
• Accession: NZ_CP015099
• Organism: Glaesserella parasuis strain SC1401

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: A4U84_RS09680
• Protein ID: WP_062924384.1
• Coordinates: 2026685..2027185 (-)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: U4SPD7
• Locus tag: A4U84_RS09685
• Protein ID: WP_005710653.1
• Coordinates: 2027175..2027462 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A4U84_RS11290	2021810..2021965	-	156	WP_005710668.1	YoaH family protein	-
A4U84_RS09650	2021983..2022711	-	729	WP_016527790.1	tRNA pseudouridine(65) synthase TruC	-
A4U84_RS09655	2022708..2023022	-	315	WP_005710664.1	YqcC family protein	-
A4U84_RS09660	2023064..2023978	-	915	WP_062924382.1	N-acetylmuramic acid 6-phosphate etherase	-
A4U84_RS09665	2023990..2025105	-	1116	WP_062924383.1	anhydro-N-acetylmuramic acid kinase	-
A4U84_RS09670	2025260..2025595	-	336	WP_005710658.1	outer membrane protein assembly factor BamE	-
A4U84_RS09675	2025656..2026657	-	1002	WP_005710656.1	nucleoid-associated protein YejK	-
A4U84_RS09680	2026685..2027185	-	501	WP_062924384.1	GNAT family N-acetyltransferase	Toxin
A4U84_RS09685	2027175..2027462	-	288	WP_005710653.1	DUF1778 domain-containing protein	Antitoxin
A4U84_RS09690	2027608..2027997	+	390	WP_005710651.1	RidA family protein	-
A4U84_RS09695	2028001..2028738	+	738	WP_035492069.1	peptidoglycan editing factor PgeF	-
A4U84_RS09700	2028913..2030490	+	1578	WP_062924385.1	FAD-binding protein	-
A4U84_RS09705	2030595..2031095	+	501	WP_021115009.1	CvpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 19115.28 Da
• Isoelectric Point: 9.2835

>T62342 WP_062924384.1 NZ_CP015099:c2027185-2026685 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYYPIPLFTLARLAVDIRYQKQGIGGMLLVKAFKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Nucleotide

• Length: 501 bp

>T62342 NZ_CP015099:c2027185-2026685 [Glaesserella parasuis]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACTACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTAGTTAAAGCTTTCAAACGCTGTGCCATCGTTGCCGAACAAGTCGGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10917.47 Da
• Isoelectric Point: 6.4650

>AT62342 WP_005710653.1 NZ_CP015099:c2027462-2027175 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Nucleotide

• Length: 288 bp

>AT62342 NZ_CP015099:c2027462-2027175 [Glaesserella parasuis]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTTACCCATACGAATATTACGGAATTTGTATTACAACGTATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Structures

Antitoxin

• AlphaFold DB: U4SPD7