Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1680163..1680785 Replicon chromosome
Accession NZ_CP015099
Organism Glaesserella parasuis strain SC1401

Toxin (Protein)


Gene name hicA Uniprot ID A0A836YYE8
Locus tag A4U84_RS08085 Protein ID WP_005715063.1
Coordinates 1680163..1680345 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A836MEP4
Locus tag A4U84_RS08090 Protein ID WP_021113997.1
Coordinates 1680372..1680785 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U84_RS08045 1675193..1676428 - 1236 WP_062924279.1 PBSX family phage terminase large subunit -
A4U84_RS08050 1676412..1676927 - 516 WP_062924280.1 terminase small subunit -
A4U84_RS08055 1677492..1677836 - 345 WP_062924281.1 DUF2570 family protein -
A4U84_RS08060 1677809..1678354 - 546 WP_062924282.1 lysozyme -
A4U84_RS08065 1678329..1678628 - 300 WP_204218662.1 hypothetical protein -
A4U84_RS08075 1678886..1679347 - 462 WP_062924283.1 antitermination protein -
A4U84_RS08080 1679337..1679915 - 579 WP_062924284.1 recombination protein NinG -
A4U84_RS08085 1680163..1680345 + 183 WP_005715063.1 type II toxin-antitoxin system HicA family toxin Toxin
A4U84_RS08090 1680372..1680785 + 414 WP_021113997.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A4U84_RS08095 1680819..1681247 - 429 WP_062924505.1 recombination protein NinB -
A4U84_RS08100 1681503..1681949 - 447 WP_081120203.1 hypothetical protein -
A4U84_RS08105 1681897..1682115 - 219 WP_062924286.1 hypothetical protein -
A4U84_RS11225 1682115..1682900 - 786 WP_075593099.1 replication protein -
A4U84_RS08115 1682897..1683583 - 687 WP_062924506.1 phage antirepressor KilAC domain-containing protein -
A4U84_RS08120 1683623..1683868 - 246 WP_021118902.1 bacteriophage CII family protein -
A4U84_RS08125 1683889..1684104 - 216 WP_021113991.1 helix-turn-helix domain-containing protein -
A4U84_RS08130 1684247..1684915 + 669 WP_021113990.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1658503..1701104 42601


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6678.80 Da        Isoelectric Point: 10.6602

>T62341 WP_005715063.1 NZ_CP015099:1680163-1680345 [Glaesserella parasuis]
VDSKTIIKMIEADGWYLVATSGSHHQFKHPTKQGRVTVPHPKKDLKKGTELSILKQAGLK

Download         Length: 183 bp

>T62341 NZ_CP015099:1680163-1680345 [Glaesserella parasuis]
GTGGATAGCAAGACCATAATCAAAATGATTGAAGCAGATGGTTGGTACTTAGTTGCAACAAGTGGAAGCCACCATCAATT
CAAACATCCAACTAAACAAGGGCGAGTAACAGTGCCTCATCCCAAAAAGGATTTAAAAAAAGGAACTGAACTCTCAATAC
TTAAACAAGCGGGGCTAAAATAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15277.32 Da        Isoelectric Point: 4.3689

>AT62341 WP_021113997.1 NZ_CP015099:1680372-1680785 [Glaesserella parasuis]
MLYPIAIEPGDETHAYGVIVPDIPGCFSAGDTLEEAYQNVKEAIVFHLEGLVEDGEDIPLPTSIENHRNNPDFTDYGMFF
GIVDVDISHLLGKAERINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Download         Length: 414 bp

>AT62341 NZ_CP015099:1680372-1680785 [Glaesserella parasuis]
ATGTTATACCCAATTGCAATTGAACCAGGTGACGAAACTCACGCTTACGGCGTTATCGTGCCTGACATTCCAGGGTGCTT
CTCTGCTGGCGATACCCTCGAAGAAGCATATCAAAATGTCAAAGAAGCCATCGTATTTCACCTTGAAGGCTTAGTTGAAG
ATGGCGAAGATATTCCATTACCAACGAGTATCGAAAATCACCGTAACAACCCTGATTTTACCGATTACGGTATGTTCTTT
GGGATTGTTGATGTTGATATTAGCCATTTACTAGGCAAAGCCGAACGCATCAACATCACCCTCCCTAGCTATCTCATCAA
ACGCATTGATGATTTTGTTGCGGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAA
TCTTAACCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YYE8

Antitoxin

Source ID Structure
AlphaFold DB A0A836MEP4

References