Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 806358..808045 Replicon chromosome
Accession NZ_CP015099
Organism Glaesserella parasuis strain SC1401

Toxin (Protein)


Gene name hipA Uniprot ID U4SB19
Locus tag A4U84_RS03770 Protein ID WP_021111224.1
Coordinates 806702..808045 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag A4U84_RS03765 Protein ID WP_015940035.1
Coordinates 806358..806702 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U84_RS03745 802426..803376 - 951 WP_005713153.1 ribose-phosphate pyrophosphokinase -
A4U84_RS03750 803404..804249 - 846 WP_021113204.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
A4U84_RS03755 804251..804883 - 633 WP_021110345.1 lipoprotein insertase outer membrane protein LolB -
A4U84_RS03760 805004..806329 - 1326 WP_035523313.1 ATP-dependent RNA helicase SrmB -
A4U84_RS03765 806358..806702 - 345 WP_015940035.1 helix-turn-helix domain-containing protein Antitoxin
A4U84_RS03770 806702..808045 - 1344 WP_021111224.1 type II toxin-antitoxin system HipA family toxin Toxin
A4U84_RS03775 808159..808596 - 438 WP_062924029.1 ribosomal protein S18-alanine N-acetyltransferase -
A4U84_RS03780 808770..808997 + 228 Protein_743 transposase -
A4U84_RS03785 809077..810756 - 1680 WP_005713398.1 DNA repair protein RecN -
A4U84_RS03790 810999..811221 - 223 Protein_745 hypothetical protein -
A4U84_RS03795 811231..812073 + 843 WP_062924032.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(161-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51106.20 Da        Isoelectric Point: 5.4867

>T62339 WP_021111224.1 NZ_CP015099:c808045-806702 [Glaesserella parasuis]
MQIEPLILQAYIADRWQDIAILTFQADYSLNDFSYLHDLTEILSDNDKAVSFNYPVEFFPHRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPMAQQNYLLLKQGTIAPVGHLRVKQAVSSFVENEPSRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATRQVWIDNLQQGASSDDFYLVKFPRGKRSVIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIETSHLVETGMFFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKGHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Download         Length: 1344 bp

>T62339 NZ_CP015099:c808045-806702 [Glaesserella parasuis]
ATGCAAATCGAACCGCTTATACTTCAAGCCTACATTGCTGATCGTTGGCAGGATATTGCTATTTTGACCTTTCAGGCTGA
TTATAGTCTCAATGATTTTAGCTATCTCCATGATTTAACAGAAATTTTAAGTGATAATGATAAGGCAGTTTCATTTAACT
ACCCTGTGGAATTTTTTCCGCATCGCAGTGTATCGGGCTGGTTTGCATTTTTAGATGATATAGTCCCTTCTGGGGCAAGC
CGGCGTTATTGGTTGCAAAAACTAGATATTGCTCATTTGCCGATGGCTCAACAAAACTATTTGTTATTAAAACAAGGCAC
GATTGCACCTGTCGGGCATTTACGAGTTAAGCAAGCGGTCAGTTCTTTTGTCGAAAATGAACCCTCTCGCTTATTTGAAA
TAGACGATGTTATCAATCGCCAAGCAGACTTTTTGGAATACGCTAATCAGCGTGGGGCAATGGCTGGCGGTGCCACAGGG
GCTGGCGGTGAAGCACCGAAATTATTGCTACGCCAAACAGCCACTCGGCAAGTTTGGATTGATAACCTACAACAAGGTGC
CTCTTCTGACGATTTCTATTTAGTCAAGTTTCCGCGTGGGAAACGTAGTGTAATAGATTGCGATATATTGAGAGCTGAAT
TTCACTATTATCACGAATTAGCCTCAATGGGTTTTGACACGATTGATACGACAAAAATGCGATTGGAAGAAGGCGAACGT
TACCCGTCGTTGTGGTTACCTCGTTTTGATGTTTATCGTAATGAACAGGGGAAAATGGCTCGTTATGCCGTTGAATCTGT
TTATGCTATGTTAGAAAAAGGGGCTGGCTCTTTGCTGGATCACGAAAAGGTTATTCGTCAGTTGATTGCTAAAATTGAAA
CCTCTCATTTGGTTGAAACAGGAATGTTTTTTGATAAACAAGCTTTTGTGATCGAGTGGGTAAGGCGAGATTTATTGAAT
ATCGCCTTTGGAAATAGCGATAATCACGGGCGAAATACGGCTTTCTTACGCAATCAAAATCGTATTTGGCTTGCTCCAAT
TTATGATTTTGCCCCAATGAAAGCAGATCCTGAAGGTATTCCTCGCACGACAATGTGGGATAGTAAAGGTCACCCTGCAT
TAGAATTAGGCGGTGAATATCGTTTTGATCTGATTGCAGAACAGCTTGATGATTTATGTCCAGCCGACAAGTTATTGGAT
GCTTTGCGTCAAACGGCTCAACAGCTTGTCGGACTTAAAGCACGTTTAGAAGCAAGGGGCGTTCCAACGGCGATTTTGAC
GTATCCTTCAATCAGTTTGGACTATTTACCTGAAAAATTAAAACGTTGGCAATTATTATCATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13225.52 Da        Isoelectric Point: 10.2782

>AT62339 WP_015940035.1 NZ_CP015099:c806702-806358 [Glaesserella parasuis]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPMNKTLLRQVLNEQAV

Download         Length: 345 bp

>AT62339 NZ_CP015099:c806702-806358 [Glaesserella parasuis]
ATGGAAGAGATCAAACAGGCGAGAGCCTCTAAAAGTAAAAAAACGTTAGATATTTATCAGAGAGCGACTGTGCGAGACGA
AATTGCTCGTAAGCTATTGCTCAATGAGATGAGTTTAGGGCAGGCGTTGAAATATCTACGTTTACATCTACTGGCAATGA
AACAAGAGCGTTATGCGGAGATTGTCAAAGTTTCTCGCAAAACGTTATCTGATTTAGAAAATGATAAGGGAAATTACAGT
ATTGATATTATCAATCAGGTGTTACGCCCCTTTGAATTACAACTAGGTGTTGTGCCAATGAACAAAACACTACTCAGACA
AGTTTTAAACGAACAAGCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U4SB19

Antitoxin

Source ID Structure

References