Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 416795..417330 Replicon chromosome
Accession NZ_CP015099
Organism Glaesserella parasuis strain SC1401

Toxin (Protein)


Gene name relE Uniprot ID A0A837AG59
Locus tag A4U84_RS01815 Protein ID WP_010785923.1
Coordinates 416795..417079 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837AF96
Locus tag A4U84_RS01820 Protein ID WP_021118772.1
Coordinates 417076..417330 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U84_RS01790 411942..412433 + 492 WP_016528224.1 acetolactate synthase small subunit -
A4U84_RS01795 412539..413360 - 822 WP_062923913.1 PHP domain-containing protein -
A4U84_RS01800 413361..413957 - 597 WP_062923914.1 DNA glycosylase -
A4U84_RS01805 413992..414951 - 960 WP_005712686.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
A4U84_RS01810 415034..416584 - 1551 WP_062923915.1 exodeoxyribonuclease I -
A4U84_RS01815 416795..417079 - 285 WP_010785923.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4U84_RS01820 417076..417330 - 255 WP_021118772.1 hypothetical protein Antitoxin
A4U84_RS01825 417447..418202 - 756 WP_062923916.1 ABC transporter permease -
A4U84_RS01830 418224..419120 - 897 WP_005712691.1 ABC transporter ATP-binding protein -
A4U84_RS01835 419126..421144 - 2019 WP_062923917.1 DNA polymerase III subunit gamma/tau -
A4U84_RS01840 421233..421775 - 543 WP_010785927.1 adenine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11233.25 Da        Isoelectric Point: 10.5362

>T62335 WP_010785923.1 NZ_CP015099:c417079-416795 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVALGK
RERNDVYQKAQLRL

Download         Length: 285 bp

>T62335 NZ_CP015099:c417079-416795 [Glaesserella parasuis]
ATGAGCTATACCATTGAATTTATCCCATCAGCAGAAAAAGAGTTTCGTAAACTAAGCTTAGATTTAAGAAAACAATTTAT
CGAAAAACTTAAAGAAAGAGCTGAAAATCCGCGTGTAGAAAGTGCTAAACTTCGTGGAATGAAAGATTGTTATAAAATCA
AATTGCGTAATGCAGGCTATCGTTTGGTGTATCAAGTGATTGATGAACGTATTGTAATCAAAGTGGTTGCACTGGGAAAA
AGGGAGCGCAACGACGTTTACCAAAAAGCACAATTACGTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 4.4131

>AT62335 WP_021118772.1 NZ_CP015099:c417330-417076 [Glaesserella parasuis]
MPSIILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT62335 NZ_CP015099:c417330-417076 [Glaesserella parasuis]
ATGCCAAGTATTATTTTAACCAATACTGTTGCGAGTATTACAGAGCTAAAGACAAATCCAATGGCGACATTCAATGCGGC
AGGCGGTGAGGCAATTGCAATTTTAAACCGAAATGAACCCGCTTTTTATTGTGTACCACCGCATATTTATGAATATCTCA
TTGAGCTTGCTGATGATGCAGAATTAGCAAAATTAGTGGAAGAACGCCAACACGAAAAAAGCTACAAAGTGGATTTAGCG
GATTTATTAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837AG59

Antitoxin

Source ID Structure
AlphaFold DB A0A837AF96

References