Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 94557..95193 Replicon chromosome
Accession NZ_CP015099
Organism Glaesserella parasuis strain SC1401

Toxin (Protein)


Gene name hicA Uniprot ID A0A836YYT4
Locus tag A4U84_RS00385 Protein ID WP_021113607.1
Coordinates 94557..94733 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A143CEF9
Locus tag A4U84_RS00390 Protein ID WP_021113608.1
Coordinates 94780..95193 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4U84_RS11585 90761..91189 + 429 Protein_73 collagen-like protein -
A4U84_RS11590 91193..91306 + 114 Protein_74 collagen-like protein -
A4U84_RS11595 91472..91600 + 129 Protein_75 hypothetical protein -
A4U84_RS11600 91646..91843 + 198 WP_202386659.1 YadA-like family protein -
A4U84_RS00360 91920..92300 - 381 WP_043896063.1 YacL family protein -
A4U84_RS00365 92384..92671 - 288 Protein_78 excinuclease ABC subunit UvrA -
A4U84_RS00370 92599..93123 - 525 WP_062923828.1 hypothetical protein -
A4U84_RS00375 93177..93680 - 504 WP_062924483.1 tail assembly protein -
A4U84_RS00380 93710..94471 - 762 WP_062924482.1 C40 family peptidase -
A4U84_RS00385 94557..94733 + 177 WP_021113607.1 type II toxin-antitoxin system HicA family toxin Toxin
A4U84_RS00390 94780..95193 + 414 WP_021113608.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A4U84_RS00395 95190..95927 - 738 WP_062923829.1 phage minor tail protein L -
A4U84_RS00400 95937..98516 - 2580 WP_062923830.1 hypothetical protein -
A4U84_RS00405 98547..99584 - 1038 WP_081120179.1 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 84024..111513 27489


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(8-63)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6704.84 Da        Isoelectric Point: 10.8513

>T62334 WP_021113607.1 NZ_CP015099:94557-94733 [Glaesserella parasuis]
MKQSEFLRWLIAQGVVKEEGSKHIKLYYNGNQSTMPRQPSKEIKNGTMRAIKKQLGLN

Download         Length: 177 bp

>T62334 NZ_CP015099:94557-94733 [Glaesserella parasuis]
ATGAAACAAAGTGAATTTTTAAGATGGCTAATTGCTCAAGGGGTAGTAAAGGAAGAAGGCTCAAAGCACATCAAACTTTA
TTACAACGGTAATCAATCAACAATGCCAAGACAACCTAGCAAGGAAATCAAAAACGGCACAATGAGAGCGATTAAAAAGC
AATTAGGTTTAAACTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15572.78 Da        Isoelectric Point: 4.3878

>AT62334 WP_021113608.1 NZ_CP015099:94780-95193 [Glaesserella parasuis]
MLYPARFEFEDGSYNVSFRDIPEALTCGDNYEDALEMAKDALLTSMDFYFEDHRKVPLPSPPQEGEVLIELPTSIFAKVL
LLNEMVDQNISNVELAKRIAVKPQEVQRITNLGHSTKIDTIARAINALDKQFELRVV

Download         Length: 414 bp

>AT62334 NZ_CP015099:94780-95193 [Glaesserella parasuis]
ATGCTGTATCCAGCACGATTCGAATTTGAAGATGGTAGTTATAATGTTTCATTCCGTGATATTCCTGAAGCGTTGACTTG
CGGTGATAACTACGAAGACGCTTTAGAGATGGCAAAAGATGCATTGCTTACCAGTATGGATTTTTATTTCGAAGATCATC
GCAAAGTACCGTTACCAAGCCCACCACAAGAAGGCGAAGTGCTGATCGAATTACCGACAAGTATTTTCGCCAAAGTGCTA
TTGCTAAATGAGATGGTCGATCAGAATATCTCCAATGTGGAATTAGCAAAACGAATTGCCGTAAAACCGCAAGAAGTACA
GCGTATTACTAATCTTGGGCATAGTACAAAAATCGATACTATTGCAAGAGCGATTAATGCACTCGACAAACAGTTTGAAT
TACGTGTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YYT4

Antitoxin

Source ID Structure
AlphaFold DB A0A143CEF9

References