Detailed information of TA system TA062331

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 8277..8823
• Replicon: plasmid pPABY8
• Accession: NZ_CP015096
• Organism: Pelagibaca abyssi strain JLT2014

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: Ga0080574_RS25155
• Protein ID: WP_076706297.1
• Coordinates: 8277..8570 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: Ga0080574_RS25160
• Protein ID: WP_076706298.1
• Coordinates: 8557..8823 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Ga0080574_RS25135	3817..4191	+	375	WP_076706293.1	hypothetical protein	-
Ga0080574_RS25140	4384..6237	+	1854	WP_076706294.1	type IV secretory system conjugative DNA transfer family protein	-
Ga0080574_RS25145	6234..6686	-	453	WP_076706295.1	hypothetical protein	-
Ga0080574_RS25150	6844..8115	+	1272	WP_083717009.1	O-antigen ligase family protein	-
Ga0080574_RS25155	8277..8570	-	294	WP_076706297.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Ga0080574_RS25160	8557..8823	-	267	WP_076706298.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
Ga0080574_RS25165	9033..9617	+	585	WP_076706299.1	recombinase family protein	-
Ga0080574_RS25170	9614..9847	+	234	WP_076706300.1	WGR domain-containing protein	-
Ga0080574_RS25175	10137..10505	-	369	WP_076706301.1	hypothetical protein	-
Ga0080574_RS25180	10505..10879	-	375	WP_076706302.1	hypothetical protein	-
Ga0080574_RS25185	11248..11733	+	486	WP_076706303.1	hypothetical protein	-
Ga0080574_RS25190	11750..12136	-	387	WP_076706304.1	type II toxin-antitoxin system death-on-curing family toxin	-
Ga0080574_RS25195	12133..12360	-	228	WP_076706305.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
Ga0080574_RS25200	12453..12677	-	225	WP_076706306.1	hypothetical protein	-
Ga0080574_RS25205	12926..13231	-	306	WP_076706307.1	hypothetical protein	-
Ga0080574_RS25210	13228..13461	-	234	WP_076706308.1	hypothetical protein	-
Ga0080574_RS25215	13458..13697	-	240	WP_076706309.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..30421	30421

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (6-65)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10871.41 Da
• Isoelectric Point: 5.5638

>T62331 WP_076706297.1 NZ_CP015096:c8570-8277 [Pelagibaca abyssi]
VTAIELTKEAERDLIDIFLFGVEHFGVAQAERYSAALMAKIESAAANPSFGADYEFVRSGLRRYEATSHAIYYRPTEEGI
LVLRILHGRMDPACHLI

Nucleotide

• Length: 294 bp

>T62331 NZ_CP015096:c8570-8277 [Pelagibaca abyssi]
GTGACAGCGATTGAACTCACCAAGGAGGCCGAGCGTGATCTGATCGACATCTTTCTGTTCGGAGTCGAGCACTTTGGTGT
TGCCCAGGCCGAGCGGTATTCTGCGGCTTTGATGGCCAAGATCGAAAGCGCCGCCGCGAACCCCAGCTTTGGCGCAGATT
ACGAATTTGTGCGCTCTGGCCTCCGTCGCTATGAAGCCACGTCTCATGCGATCTACTACAGGCCAACGGAAGAGGGTATT
CTCGTCTTGCGTATCCTTCATGGCCGCATGGACCCTGCTTGTCATCTTATTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10014.17 Da
• Isoelectric Point: 4.7064

>AT62331 WP_076706298.1 NZ_CP015096:c8823-8557 [Pelagibaca abyssi]
MSRLTISVPDQMSEWVEAQISAGRYGNVSEYFRDLVRRDQERKEAAINELRTMLDRAEASGISDKTLPEVLEAARREARQ
KGLLSDSD

Nucleotide

• Length: 267 bp

>AT62331 NZ_CP015096:c8823-8557 [Pelagibaca abyssi]
ATGTCCAGACTGACGATCTCTGTGCCCGACCAGATGAGCGAATGGGTTGAGGCGCAAATTAGCGCGGGACGTTATGGCAA
TGTCAGCGAATATTTTCGCGACCTTGTGCGGCGTGACCAAGAACGCAAAGAAGCCGCTATCAATGAGCTACGCACGATGC
TTGACCGCGCCGAGGCCAGCGGGATTAGCGACAAAACACTGCCTGAAGTGCTTGAAGCTGCCCGCCGAGAGGCGCGGCAG
AAGGGTTTATTGAGTGACAGCGATTGA