Detailed information of TA system TA062329

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-couple_hipB
• Location: 2803785..2804377
• Replicon: chromosome
• Accession: NZ_CP015093
• Organism: Pelagibaca abyssi strain JLT2014

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Ga0080574_RS17235
• Protein ID: WP_076702636.1
• Coordinates: 2804126..2804377 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Ga0080574_RS17230
• Protein ID: WP_076702634.1
• Coordinates: 2803785..2804114 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Ga0080574_RS17215	2802437..2802796	+	360	WP_076702628.1	hypothetical protein	-
Ga0080574_RS17220	2802793..2803266	+	474	WP_076702630.1	DUF1833 family protein	-
Ga0080574_RS17225	2803507..2803749	-	243	WP_076702632.1	hypothetical protein	-
Ga0080574_RS17230	2803785..2804114	-	330	WP_076702634.1	helix-turn-helix transcriptional regulator	Antitoxin
Ga0080574_RS17235	2804126..2804377	-	252	WP_076702636.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Ga0080574_RS17240	2804456..2804830	+	375	WP_076702639.1	C40 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2783008..2820182	37174

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-79)

Antitoxin

• Cro/C1-type helix-turn-helix domain (57-108)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9189.81 Da
• Isoelectric Point: 10.6218

>T62329 WP_076702636.1 NZ_CP015093:c2804377-2804126 [Pelagibaca abyssi]
MKTITYKPAALKALRKMPRPDSKRIMAKVAQYADDPAALANNVKALKGRDGIRLRVGDWRVIIDDQGEVLDVLKIGPRGG
VYD

Nucleotide

• Length: 252 bp

>T62329 NZ_CP015093:c2804377-2804126 [Pelagibaca abyssi]
ATGAAGACGATCACCTACAAGCCCGCCGCCCTGAAGGCTCTGCGCAAGATGCCGCGCCCGGACTCGAAGCGGATCATGGC
CAAGGTGGCGCAATACGCGGATGACCCGGCGGCGCTGGCGAACAACGTCAAGGCGCTGAAAGGCCGGGACGGCATCCGGC
TGCGCGTCGGCGACTGGCGCGTGATCATAGACGACCAGGGCGAGGTTCTGGACGTTCTCAAAATCGGGCCGCGTGGCGGC
GTTTACGACTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11879.35 Da
• Isoelectric Point: 4.2788

>AT62329 WP_076702634.1 NZ_CP015093:c2804114-2803785 [Pelagibaca abyssi]
MNDMITIPRAEYEALLAAREDLEDIEAYDRARAEGGESIPAAYVERILDGESPVRVFRDLRGLTQGALAEHAGVNRVTVA
ELETGRKQGSVDTLKRIAEALGVAIDDLI

Nucleotide

• Length: 330 bp

>AT62329 NZ_CP015093:c2804114-2803785 [Pelagibaca abyssi]
ATGAACGACATGATCACCATCCCCCGCGCGGAATACGAGGCGCTGCTTGCCGCGCGCGAGGATCTCGAAGACATCGAAGC
CTATGACCGCGCCAGGGCGGAAGGCGGCGAAAGCATCCCCGCCGCCTATGTCGAGCGCATTCTCGACGGCGAAAGCCCGG
TGCGGGTGTTCCGCGACCTGCGCGGCCTGACACAAGGCGCCCTCGCCGAGCACGCCGGCGTCAACCGCGTGACCGTCGCC
GAGCTCGAAACCGGCCGGAAACAGGGATCGGTCGACACCCTCAAGCGCATCGCCGAGGCGCTCGGGGTCGCGATTGACGA
TTTGATCTGA