Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 155086..155732 Replicon plasmid pPABY2
Accession NZ_CP015090
Organism Pelagibaca abyssi strain JLT2014

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Ga0080574_RS01385 Protein ID WP_076694435.1
Coordinates 155325..155732 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Ga0080574_RS01380 Protein ID WP_076694432.1
Coordinates 155086..155328 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ga0080574_RS26140 151109..151306 - 198 WP_076694420.1 hypothetical protein -
Ga0080574_RS01365 151544..152596 + 1053 WP_076694423.1 quinolinate synthase NadA -
Ga0080574_RS01370 152601..154163 + 1563 WP_076694426.1 L-aspartate oxidase -
Ga0080574_RS01375 154163..155011 + 849 WP_076694429.1 carboxylating nicotinate-nucleotide diphosphorylase -
Ga0080574_RS01380 155086..155328 + 243 WP_076694432.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Ga0080574_RS01385 155325..155732 + 408 WP_076694435.1 type II toxin-antitoxin system VapC family toxin Toxin
Ga0080574_RS01390 155757..156377 - 621 WP_076694438.1 hypothetical protein -
Ga0080574_RS01395 156544..157671 + 1128 WP_076694440.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
Ga0080574_RS01400 157675..158499 + 825 WP_076694443.1 S-formylglutathione hydrolase -
Ga0080574_RS01405 158531..158944 + 414 WP_076694446.1 cytochrome c family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..188936 188936


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-52)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14606.65 Da        Isoelectric Point: 4.6830

>T62327 WP_076694435.1 NZ_CP015090:155325-155732 [Pelagibaca abyssi]
MTLILDTNVISAARRAERAPKVAAWLAGQAETDLFLSVITLGEIERGIRLQEPKNPDFARDLRAWIERTVTVFADRLLDF
TASDAVIWGDLSARLGHSGADLMIAAQALARDATVVTGNVSDFAPTGARILDPFS

Download         Length: 408 bp

>T62327 NZ_CP015090:155325-155732 [Pelagibaca abyssi]
TTGACCCTGATCCTCGACACCAATGTGATCTCGGCGGCACGGCGGGCCGAGCGCGCGCCCAAGGTGGCGGCCTGGCTTGC
GGGGCAGGCCGAGACCGATCTGTTTCTCAGCGTCATCACGCTGGGCGAGATCGAGCGCGGCATCCGGCTGCAAGAGCCCA
AGAACCCGGATTTCGCCCGCGACCTGCGCGCCTGGATCGAGCGCACGGTCACGGTCTTTGCCGACCGGCTGCTCGATTTC
ACCGCCTCGGATGCGGTGATCTGGGGCGACCTCTCCGCCCGGCTCGGCCATTCCGGCGCCGATCTGATGATCGCGGCGCA
GGCTTTGGCGCGCGACGCGACCGTCGTCACCGGCAATGTCTCGGATTTCGCCCCCACCGGCGCGCGCATTCTCGATCCGT
TTTCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8600.73 Da        Isoelectric Point: 8.7592

>AT62327 WP_076694432.1 NZ_CP015090:155086-155328 [Pelagibaca abyssi]
MLTLQDAKNRFSAVVEAALAGRPQEVSRRGKPAVVVVSAEEYHRLTEAARANRGSFAEHLLAFPGDDIPRAGAAPRDVAF

Download         Length: 243 bp

>AT62327 NZ_CP015090:155086-155328 [Pelagibaca abyssi]
ATGCTGACCTTGCAGGACGCCAAGAACCGTTTCAGCGCGGTGGTCGAGGCGGCGCTGGCCGGGCGCCCGCAGGAGGTGTC
GCGGCGCGGCAAGCCCGCTGTCGTGGTGGTCTCTGCCGAGGAGTACCACAGGCTGACCGAGGCGGCGCGGGCCAATCGCG
GCAGCTTTGCCGAGCATCTCCTGGCCTTTCCCGGCGACGACATCCCGCGCGCCGGGGCCGCGCCGAGGGACGTGGCCTTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References