Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 100589..101207 Replicon plasmid pPABY5
Accession NZ_CP015089
Organism Pelagibaca abyssi strain JLT2014

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Ga0080574_RS00505 Protein ID WP_076694081.1
Coordinates 100806..101207 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Ga0080574_RS00500 Protein ID WP_076694079.1
Coordinates 100589..100816 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Ga0080574_RS00475 95699..97207 - 1509 WP_076694158.1 ABC transporter substrate-binding protein -
Ga0080574_RS00480 97348..97977 + 630 Protein_94 GntR family transcriptional regulator -
Ga0080574_RS00485 98113..99174 - 1062 WP_156876209.1 site-specific integrase -
Ga0080574_RS00490 99318..99860 - 543 WP_076694075.1 flavin reductase family protein -
Ga0080574_RS00495 99966..100487 - 522 WP_156876211.1 substrate-binding domain-containing protein -
Ga0080574_RS00500 100589..100816 + 228 WP_076694079.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Ga0080574_RS00505 100806..101207 + 402 WP_076694081.1 PIN domain-containing protein Toxin
Ga0080574_RS00510 101217..103184 - 1968 WP_083716691.1 TRAP transporter fused permease subunit -
Ga0080574_RS00515 103190..104146 - 957 WP_076694083.1 TAXI family TRAP transporter solute-binding subunit -
Ga0080574_RS00520 104211..104945 - 735 WP_076694162.1 class II aldolase/adducin family protein -
Ga0080574_RS00525 105057..105983 + 927 WP_076694085.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..131420 131420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14577.68 Da        Isoelectric Point: 4.4697

>T62326 WP_076694081.1 NZ_CP015089:100806-101207 [Pelagibaca abyssi]
MSDEFFDTNIILYLLSDGPKADIAERLLARGGTISVQVLNEALVNCRRKAGMSWDEAGAFLSAIRGLCEVIPLTEDIHDV
GRALSERYGFSVYDGMIVGAALSSGCTLLWSEDMHNGLLVEGRLRIRNPFAEL

Download         Length: 402 bp

>T62326 NZ_CP015089:100806-101207 [Pelagibaca abyssi]
ATGAGCGATGAGTTCTTCGATACCAATATCATCCTCTACCTGCTGAGCGACGGCCCCAAGGCCGACATCGCCGAGCGCCT
GCTGGCGCGCGGCGGCACGATCAGCGTGCAGGTGCTGAACGAGGCTTTGGTCAACTGCCGCCGCAAGGCCGGGATGAGTT
GGGACGAGGCGGGCGCCTTTCTGAGCGCGATCCGGGGTCTTTGCGAGGTGATCCCGCTGACCGAGGACATTCACGATGTC
GGTCGGGCCCTGTCCGAGCGCTATGGCTTTTCCGTATATGACGGCATGATCGTCGGCGCGGCCCTGTCGTCGGGCTGCAC
CCTGCTCTGGTCGGAAGACATGCATAACGGCCTGCTGGTCGAGGGGCGGCTGCGCATCCGCAACCCCTTTGCCGAGCTCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8369.48 Da        Isoelectric Point: 11.0140

>AT62326 WP_076694079.1 NZ_CP015089:100589-100816 [Pelagibaca abyssi]
MQVSRWGNSLAVRLPADLVRALDLKEGDRIELHADAQGLAVSRQPRADEILASLRRFRGRLPDGAQLSRDAAHER

Download         Length: 228 bp

>AT62326 NZ_CP015089:100589-100816 [Pelagibaca abyssi]
ATGCAGGTTTCCAGATGGGGCAATTCGCTGGCCGTGCGCCTGCCTGCGGATCTTGTGCGCGCGCTCGATCTGAAAGAGGG
TGACCGGATCGAGCTGCACGCGGATGCCCAGGGCCTGGCCGTGTCGCGCCAGCCCCGTGCAGACGAGATCCTCGCCAGCC
TGCGGCGGTTCCGGGGGCGGCTGCCCGACGGCGCGCAGCTGAGCCGCGACGCCGCGCATGAGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References