Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2307020..2307650 Replicon chromosome
Accession NZ_CP015081
Organism Deinococcus radiodurans R1

Toxin (Protein)


Gene name mazF Uniprot ID Q9RX98
Locus tag A2G07_RS11445 Protein ID WP_010887062.1
Coordinates 2307297..2307650 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag A2G07_RS11440 Protein ID WP_162177573.1
Coordinates 2307020..2307244 (-) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2G07_RS11415 2302508..2302687 + 180 WP_028328008.1 hypothetical protein -
A2G07_RS11420 2302808..2303584 + 777 WP_010887067.1 trans-aconitate 2-methyltransferase -
A2G07_RS11425 2303740..2303964 + 225 WP_162177572.1 hypothetical protein -
A2G07_RS11430 2304145..2306613 - 2469 WP_010887065.1 ATP-dependent helicase HrpB -
A2G07_RS11435 2306610..2307023 - 414 WP_010887064.1 type II toxin-antitoxin system VapC family toxin -
A2G07_RS11440 2307020..2307244 - 225 WP_162177573.1 hypothetical protein Antitoxin
A2G07_RS11445 2307297..2307650 - 354 WP_010887062.1 endoribonuclease MazF Toxin
A2G07_RS11450 2307644..2307886 - 243 WP_010887061.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
A2G07_RS11455 2308066..2309547 + 1482 Protein_2261 carboxylesterase/lipase family protein -
A2G07_RS11460 2309595..2310224 - 630 WP_027479568.1 HAD family hydrolase -
A2G07_RS11465 2310226..2310405 - 180 WP_034349506.1 hypothetical protein -
A2G07_RS11470 2310428..2311390 - 963 WP_034349507.1 NAD(P)/FAD-dependent oxidoreductase -
A2G07_RS11475 2311411..2312094 - 684 WP_010887056.1 SDR family oxidoreductase -
A2G07_RS11480 2312091..2312462 - 372 Protein_2266 inorganic pyrophosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-112)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 118 a.a.        Molecular weight: 12450.24 Da        Isoelectric Point: 7.3219

>T62284 WP_010887062.1 NZ_CP015081:c2307650-2307297 [Deinococcus radiodurans R1]
MVSDYVPDAGHLVWLNFTPQAGHEQGGRRPALVLSPAAYNGVTGLMQACPVTSRAKGYPFEVTLPAHLGVSGVVLADHCR
SLDWRSRRAEQLAEAPADVLAEVRGKLGSLLGMSEKA

Download         Length: 354 bp

>T62284 NZ_CP015081:c2307650-2307297 [Deinococcus radiodurans R1]
ATGGTAAGCGATTATGTCCCGGACGCTGGGCATCTGGTGTGGCTCAACTTCACACCTCAGGCAGGGCATGAACAGGGGGG
ACGGCGACCGGCGCTGGTGCTTTCGCCTGCCGCTTATAACGGCGTCACTGGACTGATGCAGGCGTGTCCGGTGACCAGCC
GCGCCAAGGGGTATCCGTTTGAAGTGACGCTCCCTGCTCACCTTGGAGTCAGCGGCGTGGTGCTGGCCGACCATTGCCGC
AGCCTCGACTGGCGCAGTCGCCGGGCCGAACAACTTGCGGAGGCGCCGGCGGACGTCCTGGCCGAAGTCCGTGGCAAGTT
GGGCAGCTTGCTGGGCATGTCCGAGAAGGCATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8229.23 Da        Isoelectric Point: 4.3481

>AT62284 WP_162177573.1 NZ_CP015081:c2307244-2307020 [Deinococcus radiodurans R1]
MTTLEARIENGKVVLTPEQAAELGLREGEVLPVTIAPHEAETEGNPFTRWIGTLPPLPDGEESARFYRRLRDGE

Download         Length: 225 bp

>AT62284 NZ_CP015081:c2307244-2307020 [Deinococcus radiodurans R1]
ATGACGACGTTGGAGGCCCGGATTGAGAACGGCAAGGTGGTGCTCACCCCTGAGCAGGCCGCCGAACTGGGCCTGCGCGA
AGGCGAAGTGCTGCCGGTGACGATTGCGCCGCACGAAGCGGAAACGGAAGGCAACCCCTTCACCCGCTGGATTGGGACGC
TCCCCCCACTGCCTGACGGTGAAGAGTCTGCGCGGTTCTACCGCCGCCTGCGAGACGGCGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7D2M
PDB 7D2P
PDB 7DHP
PDB 7D2Q
PDB 7D28
PDB 7D2N


Antitoxin

Source ID Structure

References