Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 3350003..3350535 Replicon chromosome
Accession NZ_CP015080
Organism Desulfuromonas sp. DDH964

Toxin (Protein)


Gene name parE Uniprot ID A0A143BBJ6
Locus tag DBW_RS15315 Protein ID WP_066728613.1
Coordinates 3350242..3350535 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A143BB70
Locus tag DBW_RS15310 Protein ID WP_066728611.1
Coordinates 3350003..3350242 (+) Length 80 a.a.

Genomic Context

DBW_RS15290DBW_RS15295DBW_RS15300DBW_RS15310DBW_RS15315DBW_RS15325DBW_RS15335DBW_RS15340DBW_RS15305DBW_RS15320DBW_RS15330
Location: 3345459..3346574 (1116 bp)
Type: Others
Protein ID: WP_066728605.1
Location: 3346643..3347182 (540 bp)
Type: Others
Protein ID: WP_066728607.1
Location: 3347235..3348530 (1296 bp)
Type: Others
Protein ID: WP_066728609.1
Location: 3350003..3350242 (240 bp)
Type: Antitoxin
Protein ID: WP_066728611.1
Location: 3350242..3350535 (294 bp)
Type: Toxin
Protein ID: WP_066728613.1
Location: 3352169..3352594 (426 bp)
Type: Others
Protein ID: WP_066728616.1
Location: 3353196..3353663 (468 bp)
Type: Others
Protein ID: WP_066728618.1
Location: 3353735..3355003 (1269 bp)
Type: Others
Protein ID: WP_066728620.1
Location: 3348830..3349786 (957 bp)
Type: Others
Protein ID: WP_066723323.1
Location: 3350753..3351979 (1227 bp)
Type: Others
Protein ID: WP_197463662.1
Location: 3352676..3352984 (309 bp)
Type: Others
Protein ID: WP_066728617.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DBW_RS152903345459..3346574+1116WP_066728605.1TRAP transporter substrate-binding protein-
DBW_RS152953346643..3347182+540WP_066728607.1TRAP transporter small permease subunit-
DBW_RS153003347235..3348530+1296WP_066728609.1TRAP transporter large permease subunit-
DBW_RS153053348830..3349786-957WP_066723323.1IS1595 family transposase-
DBW_RS153103350003..3350242+240WP_066728611.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
DBW_RS153153350242..3350535+294WP_066728613.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DBW_RS153203350753..3351979-1227WP_197463662.1MFS transporter-
DBW_RS153253352169..3352594+426WP_066728616.1hypothetical protein-
DBW_RS153303352676..3352984-309WP_066728617.1hypothetical protein-
DBW_RS153353353196..3353663+468WP_066728618.1Lrp/AsnC family transcriptional regulator-
DBW_RS153403353735..3355003+1269WP_066728620.1diaminopimelate decarboxylase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--3348830..3349786956


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-75)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11745.50 Da        Isoelectric Point: 10.4727

>T62282 WP_066728613.1 NZ_CP015080:3350242-3350535 [Desulfuromonas sp. DDH964]
MPLFTLTKRALEDLREIGRYTQGRWGREQRRTYLVQLDRCFRALAENPNQGERLDRVRPGYRKYPTGRHVIYYRTQSPGM
IEIVRVLHERMDIETHL

Download         Length: 294 bp

>T62282 NZ_CP015080:3350242-3350535 [Desulfuromonas sp. DDH964]
ATGCCGCTATTTACGCTGACAAAGCGCGCCCTCGAAGACCTCCGGGAGATCGGCCGCTACACTCAAGGACGATGGGGGCG
CGAGCAGCGGCGCACATATCTGGTTCAACTCGATCGCTGTTTTCGTGCTCTTGCCGAAAACCCAAACCAGGGTGAACGCT
TAGACCGGGTTCGTCCCGGCTACCGCAAATATCCCACCGGCCGCCACGTCATCTATTATCGCACGCAGAGCCCCGGCATG
ATCGAAATCGTGCGCGTCTTGCATGAGCGAATGGACATCGAGACGCATCTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.94 Da        Isoelectric Point: 4.7105

>AT62282 WP_066728611.1 NZ_CP015080:3350003-3350242 [Desulfuromonas sp. DDH964]
MGKNTSVTLGEHYERFISHAIEEGRYGSTSEAIRAGLRLLEERETRLEVLRRALVEGEQSGMADYSLDALNRELDKELG

Download         Length: 240 bp

>AT62282 NZ_CP015080:3350003-3350242 [Desulfuromonas sp. DDH964]
ATGGGCAAAAACACCAGCGTCACCTTGGGCGAACACTACGAGAGATTTATTTCCCACGCGATCGAAGAAGGCCGCTATGG
CTCGACCAGCGAGGCAATCCGCGCCGGTCTACGCCTGCTAGAGGAGCGTGAGACGCGGTTGGAGGTGCTGCGCCGGGCAC
TGGTCGAGGGCGAGCAAAGCGGTATGGCGGATTACTCCTTGGACGCCTTAAACCGCGAACTTGACAAGGAACTCGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A143BBJ6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A143BB70

References