Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 3350003..3350535 Replicon chromosome
Accession NZ_CP015080
Organism Desulfuromonas sp. DDH964

Toxin (Protein)


Gene name parE Uniprot ID A0A143BBJ6
Locus tag DBW_RS15315 Protein ID WP_066728613.1
Coordinates 3350242..3350535 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A143BB70
Locus tag DBW_RS15310 Protein ID WP_066728611.1
Coordinates 3350003..3350242 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBW_RS15290 3345459..3346574 + 1116 WP_066728605.1 TRAP transporter substrate-binding protein -
DBW_RS15295 3346643..3347182 + 540 WP_066728607.1 TRAP transporter small permease subunit -
DBW_RS15300 3347235..3348530 + 1296 WP_066728609.1 TRAP transporter large permease subunit -
DBW_RS15305 3348830..3349786 - 957 WP_066723323.1 IS1595 family transposase -
DBW_RS15310 3350003..3350242 + 240 WP_066728611.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DBW_RS15315 3350242..3350535 + 294 WP_066728613.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DBW_RS15320 3350753..3351979 - 1227 WP_197463662.1 MFS transporter -
DBW_RS15325 3352169..3352594 + 426 WP_066728616.1 hypothetical protein -
DBW_RS15330 3352676..3352984 - 309 WP_066728617.1 hypothetical protein -
DBW_RS15335 3353196..3353663 + 468 WP_066728618.1 Lrp/AsnC family transcriptional regulator -
DBW_RS15340 3353735..3355003 + 1269 WP_066728620.1 diaminopimelate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3348830..3349786 956


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-75)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11745.50 Da        Isoelectric Point: 10.4727

>T62282 WP_066728613.1 NZ_CP015080:3350242-3350535 [Desulfuromonas sp. DDH964]
MPLFTLTKRALEDLREIGRYTQGRWGREQRRTYLVQLDRCFRALAENPNQGERLDRVRPGYRKYPTGRHVIYYRTQSPGM
IEIVRVLHERMDIETHL

Download         Length: 294 bp

>T62282 NZ_CP015080:3350242-3350535 [Desulfuromonas sp. DDH964]
ATGCCGCTATTTACGCTGACAAAGCGCGCCCTCGAAGACCTCCGGGAGATCGGCCGCTACACTCAAGGACGATGGGGGCG
CGAGCAGCGGCGCACATATCTGGTTCAACTCGATCGCTGTTTTCGTGCTCTTGCCGAAAACCCAAACCAGGGTGAACGCT
TAGACCGGGTTCGTCCCGGCTACCGCAAATATCCCACCGGCCGCCACGTCATCTATTATCGCACGCAGAGCCCCGGCATG
ATCGAAATCGTGCGCGTCTTGCATGAGCGAATGGACATCGAGACGCATCTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8924.94 Da        Isoelectric Point: 4.7105

>AT62282 WP_066728611.1 NZ_CP015080:3350003-3350242 [Desulfuromonas sp. DDH964]
MGKNTSVTLGEHYERFISHAIEEGRYGSTSEAIRAGLRLLEERETRLEVLRRALVEGEQSGMADYSLDALNRELDKELG

Download         Length: 240 bp

>AT62282 NZ_CP015080:3350003-3350242 [Desulfuromonas sp. DDH964]
ATGGGCAAAAACACCAGCGTCACCTTGGGCGAACACTACGAGAGATTTATTTCCCACGCGATCGAAGAAGGCCGCTATGG
CTCGACCAGCGAGGCAATCCGCGCCGGTCTACGCCTGCTAGAGGAGCGTGAGACGCGGTTGGAGGTGCTGCGCCGGGCAC
TGGTCGAGGGCGAGCAAAGCGGTATGGCGGATTACTCCTTGGACGCCTTAAACCGCGAACTTGACAAGGAACTCGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143BBJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A143BB70

References