Detailed information of TA system TA062281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3230174..3230823
• Replicon: chromosome
• Accession: NZ_CP015080
• Organism: Desulfuromonas sp. DDH964

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A143BB26
• Locus tag: DBW_RS14820
• Protein ID: WP_066728427.1
• Coordinates: 3230401..3230823 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DBW_RS18245
• Protein ID: WP_197463789.1
• Coordinates: 3230174..3230407 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBW_RS14805	3225556..3226989	-	1434	WP_066728421.1	sigma-54 dependent transcriptional regulator	-
DBW_RS14810	3226989..3229412	-	2424	WP_197463654.1	PAS domain S-box protein	-
DBW_RS18245	3230174..3230407	+	234	WP_197463789.1	antitoxin	Antitoxin
DBW_RS14820	3230401..3230823	+	423	WP_066728427.1	tRNA(fMet)-specific endonuclease VapC	Toxin
DBW_RS14825	3230854..3231729	-	876	WP_066728429.1	transposase	-
DBW_RS14830	3231861..3232133	+	273	WP_066728431.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
DBW_RS14835	3232121..3232525	+	405	WP_066728432.1	type II toxin-antitoxin system VapC family toxin	-
DBW_RS18625	3232855..3233118	-	264	WP_157471914.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (6-54)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15728.15 Da
• Isoelectric Point: 7.2426

>T62281 WP_066728427.1 NZ_CP015080:3230401-3230823 [Desulfuromonas sp. DDH964]
MLKYMLDTNIIIYTLKNRPAQVRTMFKQHEGQMCISTVTLGELVFGAENSQQIERNLADIESMISRLEVLPFDNKAAQHF
GQIRADLYRKGQPIGPYDMMIAGHARACGLQLVSNNVKEFSRIPGLILENWATATPDSAT

Nucleotide

• Length: 423 bp

>T62281 NZ_CP015080:3230401-3230823 [Desulfuromonas sp. DDH964]
ATGCTGAAGTATATGCTTGACACAAATATCATTATCTACACGCTCAAAAATCGTCCCGCACAGGTCAGAACTATGTTCAA
GCAGCATGAAGGCCAAATGTGTATTTCGACTGTAACCTTGGGGGAATTGGTTTTCGGCGCGGAAAATTCTCAGCAGATAG
AACGAAACCTGGCAGACATAGAGTCAATGATATCCCGCCTCGAAGTCCTTCCGTTTGACAACAAAGCCGCACAGCATTTT
GGGCAGATACGCGCCGACCTCTACCGCAAAGGGCAACCCATCGGACCCTACGATATGATGATTGCCGGTCACGCGAGAGC
TTGTGGGTTGCAACTGGTGTCCAATAATGTAAAAGAATTTTCCAGGATACCAGGCCTTATCCTTGAAAACTGGGCAACAG
CAACCCCGGATTCGGCAACATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8747.82 Da
• Isoelectric Point: 4.9802

>AT62281 WP_197463789.1 NZ_CP015080:3230174-3230407 [Desulfuromonas sp. DDH964]
VRTRVFKSNKSQAVRLPKAIAFPDSIQDVEITAIGNTRIISPVGQSWDDWFDSPGVSADFMAERQQPDDQLREKWPC

Nucleotide

• Length: 234 bp

>AT62281 NZ_CP015080:3230174-3230407 [Desulfuromonas sp. DDH964]
GTGCGAACTCGCGTCTTCAAAAGCAACAAAAGTCAGGCCGTAAGGTTGCCCAAAGCGATCGCTTTTCCTGATTCAATTCA
AGACGTTGAAATTACTGCCATTGGAAATACACGAATTATTTCACCGGTTGGTCAATCCTGGGATGATTGGTTTGATTCCC
CGGGAGTATCGGCAGATTTCATGGCAGAGCGCCAACAGCCCGACGATCAATTGCGAGAAAAGTGGCCATGCTGA

Structures

Toxin

• AlphaFold DB: A0A143BB26