Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3230174..3230823 Replicon chromosome
Accession NZ_CP015080
Organism Desulfuromonas sp. DDH964

Toxin (Protein)


Gene name vapC Uniprot ID A0A143BB26
Locus tag DBW_RS14820 Protein ID WP_066728427.1
Coordinates 3230401..3230823 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DBW_RS18245 Protein ID WP_197463789.1
Coordinates 3230174..3230407 (+) Length 78 a.a.

Genomic Context

DBW_RS18245DBW_RS14820DBW_RS14830DBW_RS14835DBW_RS14805DBW_RS14810DBW_RS14825DBW_RS18625
Location: 3230174..3230407 (234 bp)
Type: Antitoxin
Protein ID: WP_197463789.1
Location: 3230401..3230823 (423 bp)
Type: Toxin
Protein ID: WP_066728427.1
Location: 3231861..3232133 (273 bp)
Type: Others
Protein ID: WP_066728431.1
Location: 3232121..3232525 (405 bp)
Type: Others
Protein ID: WP_066728432.1
Location: 3225556..3226989 (1434 bp)
Type: Others
Protein ID: WP_066728421.1
Location: 3226989..3229412 (2424 bp)
Type: Others
Protein ID: WP_197463654.1
Location: 3230854..3231729 (876 bp)
Type: Others
Protein ID: WP_066728429.1
Location: 3232855..3233118 (264 bp)
Type: Others
Protein ID: WP_157471914.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DBW_RS148053225556..3226989-1434WP_066728421.1sigma-54 dependent transcriptional regulator-
DBW_RS148103226989..3229412-2424WP_197463654.1PAS domain S-box protein-
DBW_RS182453230174..3230407+234WP_197463789.1antitoxinAntitoxin
DBW_RS148203230401..3230823+423WP_066728427.1tRNA(fMet)-specific endonuclease VapCToxin
DBW_RS148253230854..3231729-876WP_066728429.1transposase-
DBW_RS148303231861..3232133+273WP_066728431.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DBW_RS148353232121..3232525+405WP_066728432.1type II toxin-antitoxin system VapC family toxin-
DBW_RS186253232855..3233118-264WP_157471914.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(6-54)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15728.15 Da        Isoelectric Point: 7.2426

>T62281 WP_066728427.1 NZ_CP015080:3230401-3230823 [Desulfuromonas sp. DDH964]
MLKYMLDTNIIIYTLKNRPAQVRTMFKQHEGQMCISTVTLGELVFGAENSQQIERNLADIESMISRLEVLPFDNKAAQHF
GQIRADLYRKGQPIGPYDMMIAGHARACGLQLVSNNVKEFSRIPGLILENWATATPDSAT

Download         Length: 423 bp

>T62281 NZ_CP015080:3230401-3230823 [Desulfuromonas sp. DDH964]
ATGCTGAAGTATATGCTTGACACAAATATCATTATCTACACGCTCAAAAATCGTCCCGCACAGGTCAGAACTATGTTCAA
GCAGCATGAAGGCCAAATGTGTATTTCGACTGTAACCTTGGGGGAATTGGTTTTCGGCGCGGAAAATTCTCAGCAGATAG
AACGAAACCTGGCAGACATAGAGTCAATGATATCCCGCCTCGAAGTCCTTCCGTTTGACAACAAAGCCGCACAGCATTTT
GGGCAGATACGCGCCGACCTCTACCGCAAAGGGCAACCCATCGGACCCTACGATATGATGATTGCCGGTCACGCGAGAGC
TTGTGGGTTGCAACTGGTGTCCAATAATGTAAAAGAATTTTCCAGGATACCAGGCCTTATCCTTGAAAACTGGGCAACAG
CAACCCCGGATTCGGCAACATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8747.82 Da        Isoelectric Point: 4.9802

>AT62281 WP_197463789.1 NZ_CP015080:3230174-3230407 [Desulfuromonas sp. DDH964]
VRTRVFKSNKSQAVRLPKAIAFPDSIQDVEITAIGNTRIISPVGQSWDDWFDSPGVSADFMAERQQPDDQLREKWPC

Download         Length: 234 bp

>AT62281 NZ_CP015080:3230174-3230407 [Desulfuromonas sp. DDH964]
GTGCGAACTCGCGTCTTCAAAAGCAACAAAAGTCAGGCCGTAAGGTTGCCCAAAGCGATCGCTTTTCCTGATTCAATTCA
AGACGTTGAAATTACTGCCATTGGAAATACACGAATTATTTCACCGGTTGGTCAATCCTGGGATGATTGGTTTGATTCCC
CGGGAGTATCGGCAGATTTCATGGCAGAGCGCCAACAGCCCGACGATCAATTGCGAGAAAAGTGGCCATGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A143BB26

Antitoxin

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Source
ID
Structure
No matching records found

References