Detailed information of TA system TA062280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 3210212..3210689
• Replicon: chromosome
• Accession: NZ_CP015080
• Organism: Desulfuromonas sp. DDH964

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: DBW_RS18240
• Protein ID: WP_082820381.1
• Coordinates: 3210423..3210689 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A143BAF7
• Locus tag: DBW_RS14760
• Protein ID: WP_066728409.1
• Coordinates: 3210212..3210439 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBW_RS14740	3206381..3206986	-	606	WP_066728402.1	DedA family protein	-
DBW_RS18825	3206995..3207699	-	705	WP_066728404.1	alpha/beta hydrolase	-
DBW_RS18830	3207893..3208639	+	747	WP_066728406.1	hypothetical protein	-
DBW_RS14755	3208685..3210055	+	1371	WP_066728407.1	MBL fold metallo-hydrolase	-
DBW_RS14760	3210212..3210439	+	228	WP_066728409.1	CopG family transcriptional regulator	Antitoxin
DBW_RS18240	3210423..3210689	+	267	WP_082820381.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DBW_RS14765	3210790..3211158	-	369	WP_197463653.1	hypothetical protein	-
DBW_RS14770	3211778..3212617	+	840	WP_066728411.1	SUMF1/EgtB/PvdO family nonheme iron enzyme	-
DBW_RS14775	3212703..3214043	+	1341	WP_066728413.1	tetratricopeptide repeat protein	-
DBW_RS18620	3214095..3214253	-	159	WP_157471911.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3210212..3218281	8069

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10038.78 Da
• Isoelectric Point: 10.5803

>T62280 WP_082820381.1 NZ_CP015080:3210423-3210689 [Desulfuromonas sp. DDH964]
MTWTIKYTSTAKVQLRKLDRPVAARILDYMDQRVAILDDPRTLGKALSGNLGGLWRYRVGDCRVICEIQGTSVSILVVKI
GNRREVYR

Nucleotide

• Length: 267 bp

>T62280 NZ_CP015080:3210423-3210689 [Desulfuromonas sp. DDH964]
TTGACCTGGACGATTAAATACACCAGCACTGCAAAAGTCCAGTTGCGCAAACTCGACAGACCGGTTGCTGCACGTATTCT
CGACTACATGGATCAGCGTGTCGCCATTCTGGATGATCCGCGCACGTTGGGAAAGGCCCTGTCCGGCAATCTGGGAGGAC
TCTGGCGTTACCGTGTTGGTGACTGCCGGGTCATCTGCGAGATACAAGGCACCAGTGTAAGCATCCTCGTAGTTAAGATC
GGCAATCGCCGCGAGGTCTACAGATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8684.69 Da
• Isoelectric Point: 4.1860

>AT62280 WP_066728409.1 NZ_CP015080:3210212-3210439 [Desulfuromonas sp. DDH964]
MATSIRIAPETEKRLDFLASQTGRTKAFYLRELIERGLEDLEDYYLAADVLERVRKGEEEIYSAAEVRESLDLDD

Nucleotide

• Length: 228 bp

>AT62280 NZ_CP015080:3210212-3210439 [Desulfuromonas sp. DDH964]
ATGGCCACATCGATACGCATCGCCCCTGAGACGGAAAAACGACTTGACTTTCTCGCCAGTCAGACAGGGCGCACCAAAGC
TTTTTACCTGCGGGAACTGATCGAACGCGGACTGGAGGATTTGGAAGATTATTACCTTGCCGCCGATGTTCTGGAGCGGG
TACGCAAAGGCGAGGAAGAGATTTATTCTGCTGCCGAGGTAAGAGAATCCCTTGACCTGGACGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A143BAF7