Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2679878..2680476 Replicon chromosome
Accession NZ_CP015080
Organism Desulfuromonas sp. DDH964

Toxin (Protein)


Gene name hicA Uniprot ID A0A143B930
Locus tag DBW_RS12350 Protein ID WP_066727810.1
Coordinates 2679878..2680132 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A143B8X3
Locus tag DBW_RS12355 Protein ID WP_066727811.1
Coordinates 2680129..2680476 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBW_RS12325 2675005..2675163 + 159 WP_066727805.1 rubredoxin -
DBW_RS12330 2675197..2675937 - 741 WP_066727806.1 methylenetetrahydrofolate reductase -
DBW_RS12335 2676064..2676681 - 618 WP_066727807.1 DeoR/GlpR family DNA-binding transcription regulator -
DBW_RS12340 2676930..2677637 + 708 WP_066727808.1 energy transducer TonB -
DBW_RS12345 2677715..2679718 + 2004 WP_066727809.1 TonB-dependent receptor -
DBW_RS12350 2679878..2680132 + 255 WP_066727810.1 type II toxin-antitoxin system HicA family toxin Toxin
DBW_RS12355 2680129..2680476 + 348 WP_066727811.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DBW_RS12360 2680838..2682097 + 1260 WP_066727812.1 HD domain-containing protein -
DBW_RS12365 2682125..2682787 + 663 WP_066727813.1 hypothetical protein -
DBW_RS12370 2682927..2684999 - 2073 WP_066727814.1 transketolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9645.23 Da        Isoelectric Point: 10.6187

>T62279 WP_066727810.1 NZ_CP015080:2679878-2680132 [Desulfuromonas sp. DDH964]
MTRRDKLLQRFCNRPKDFTWQELATLLAGFGYHPAVAGKTGGSRVRFLHDTRAPIILHKPHPTPVLKHYQVEQIKETLAQ
EGLL

Download         Length: 255 bp

>T62279 NZ_CP015080:2679878-2680132 [Desulfuromonas sp. DDH964]
ATGACCAGACGCGACAAGCTGTTGCAGCGCTTCTGCAACCGACCGAAGGATTTCACCTGGCAGGAATTGGCAACCCTGCT
GGCTGGATTCGGCTACCATCCGGCAGTTGCCGGCAAGACCGGAGGTTCGCGGGTCAGGTTCCTGCACGATACGCGAGCCC
CCATCATCCTGCATAAACCCCATCCGACCCCGGTCTTGAAGCACTATCAAGTGGAACAGATCAAGGAAACACTCGCCCAA
GAGGGTTTACTATGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13100.84 Da        Isoelectric Point: 6.2339

>AT62279 WP_066727811.1 NZ_CP015080:2680129-2680476 [Desulfuromonas sp. DDH964]
MKDMMRYRDYFGSVHYSDEDRVFFGRVEFIRALVSYEGTDVTSLRRSFEEAVDDYLETCQAAGHVPEKPFKGSFNVRVGA
ALHQRVAIAASQRGMTLNKFIVEVLEREAGKDLAV

Download         Length: 348 bp

>AT62279 NZ_CP015080:2680129-2680476 [Desulfuromonas sp. DDH964]
ATGAAAGACATGATGCGTTACCGGGACTATTTCGGTTCCGTCCATTACAGCGACGAGGATCGCGTCTTCTTCGGCCGCGT
GGAGTTTATCCGCGCCCTGGTGAGTTACGAAGGAACCGACGTCACCTCCCTGCGCCGTTCCTTCGAGGAAGCGGTCGACG
ACTATCTGGAAACCTGCCAGGCGGCAGGCCACGTCCCGGAAAAACCGTTCAAGGGCTCCTTCAACGTCCGCGTCGGCGCT
GCCCTGCACCAGCGCGTCGCCATCGCCGCGAGCCAGCGGGGAATGACCTTGAACAAGTTCATCGTCGAGGTGTTGGAACG
GGAGGCGGGAAAAGATCTGGCAGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A143B930

Antitoxin

Source ID Structure
AlphaFold DB A0A143B8X3

References