Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1689009..1689840 Replicon chromosome
Accession NZ_CP015076
Organism Escherichia coli strain Ecol_448

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag A4R37_RS08940 Protein ID WP_000854814.1
Coordinates 1689466..1689840 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A641DSP2
Locus tag A4R37_RS08935 Protein ID WP_001546021.1
Coordinates 1689009..1689377 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R37_RS08900 1684067..1685137 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
A4R37_RS08905 1685273..1685950 + 678 WP_001362823.1 hypothetical protein -
A4R37_RS08910 1685966..1686376 + 411 WP_000846704.1 hypothetical protein -
A4R37_RS08915 1686597..1687417 + 821 Protein_1700 DUF945 domain-containing protein -
A4R37_RS08920 1687680..1688153 + 474 WP_001385393.1 antirestriction protein -
A4R37_RS08925 1688169..1688645 + 477 WP_001186773.1 RadC family protein -
A4R37_RS08930 1688708..1688929 + 222 WP_000692323.1 DUF987 domain-containing protein -
A4R37_RS08935 1689009..1689377 + 369 WP_001546021.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
A4R37_RS08940 1689466..1689840 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
A4R37_RS08945 1689837..1690031 + 195 WP_000988601.1 hypothetical protein -
A4R37_RS29040 1690044..1690157 + 114 WP_001161660.1 DUF957 domain-containing protein -
A4R37_RS08955 1690520..1691266 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
A4R37_RS08960 1691281..1692822 - 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
A4R37_RS29045 1693033..1693179 - 147 Protein_1710 transposase domain-containing protein -
A4R37_RS29050 1693233..1693415 + 183 WP_001016348.1 hypothetical protein -
A4R37_RS08970 1693516..1693845 - 330 WP_000450409.1 DUF496 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T62248 WP_000854814.1 NZ_CP015076:1689466-1689840 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T62248 NZ_CP015076:1689466-1689840 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTACTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13607.47 Da        Isoelectric Point: 6.3139

>AT62248 WP_001546021.1 NZ_CP015076:1689009-1689377 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGLFSDADAYHPDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT62248 NZ_CP015076:1689009-1689377 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCAGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A641DSP2

References