Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2418754..2419289 Replicon chromosome
Accession NZ_CP015064
Organism Mesorhizobium ciceri biovar biserrulae strain WSM1284

Toxin (Protein)


Gene name relE Uniprot ID A0A807AIF1
Locus tag A4R29_RS10960 Protein ID WP_063171900.1
Coordinates 2419014..2419289 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A807AK59
Locus tag A4R29_RS10955 Protein ID WP_063171899.1
Coordinates 2418754..2419014 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R29_RS10930 2414250..2415563 + 1314 WP_013532252.1 serine hydroxymethyltransferase -
A4R29_RS10935 2415640..2416305 + 666 WP_063171896.1 hypothetical protein -
A4R29_RS10940 2416463..2416942 + 480 WP_013532250.1 transcriptional regulator NrdR -
A4R29_RS10945 2416945..2418060 + 1116 WP_063171897.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
A4R29_RS10950 2418073..2418690 + 618 WP_063171898.1 riboflavin synthase -
A4R29_RS10955 2418754..2419014 + 261 WP_063171899.1 ribbon-helix-helix domain-containing protein Antitoxin
A4R29_RS10960 2419014..2419289 + 276 WP_063171900.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R29_RS10965 2419371..2419865 + 495 WP_013532245.1 6,7-dimethyl-8-ribityllumazine synthase -
A4R29_RS10970 2419862..2420362 + 501 WP_013532244.1 transcription antitermination factor NusB -
A4R29_RS10975 2420359..2421570 + 1212 WP_063171901.1 MFS transporter -
A4R29_RS10980 2421579..2422151 - 573 WP_013532242.1 NAD(P)H-dependent oxidoreductase -
A4R29_RS10985 2422356..2423267 + 912 WP_013532241.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10674.23 Da        Isoelectric Point: 7.2041

>T62155 WP_063171900.1 NZ_CP015064:2419014-2419289 [Mesorhizobium ciceri biovar biserrulae]
MELKWTNKALSDLVRLHDFLVLENGPAAARAVQSLTAAPARLVEYPRIGERLEEFEPREVRRILVGSYEIRYEIQNTTIS
VLRLWHTREDR

Download         Length: 276 bp

>T62155 NZ_CP015064:2419014-2419289 [Mesorhizobium ciceri biovar biserrulae]
ATGGAGTTGAAATGGACCAACAAGGCTTTGTCCGACTTGGTCCGGCTACATGATTTTCTCGTGCTAGAAAATGGCCCGGC
GGCCGCACGTGCCGTGCAGTCGCTTACTGCCGCGCCGGCACGGTTGGTCGAATATCCGCGCATCGGTGAGAGACTGGAAG
AGTTCGAACCACGAGAAGTGCGTCGCATTTTGGTAGGCAGCTACGAAATTCGTTACGAGATACAGAACACGACAATTTCT
GTGTTGCGCCTGTGGCATACGCGAGAGGATCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9616.09 Da        Isoelectric Point: 5.6994

>AT62155 WP_063171899.1 NZ_CP015064:2418754-2419014 [Mesorhizobium ciceri biovar biserrulae]
MDTKVITAHVPLPLAEKVDQLAARLERPRGWIVKQALSAWVDLEEERRRLTLEAMADVDAGRVIDHQAVQAWAESLGADK
PLPVPR

Download         Length: 261 bp

>AT62155 NZ_CP015064:2418754-2419014 [Mesorhizobium ciceri biovar biserrulae]
ATGGATACAAAAGTAATCACCGCTCACGTTCCGCTGCCGCTGGCTGAAAAGGTAGATCAACTGGCTGCCCGCCTTGAGCG
CCCACGCGGCTGGATCGTCAAACAAGCTCTTTCCGCGTGGGTGGATTTGGAGGAGGAGCGCCGACGGCTCACGCTTGAAG
CAATGGCCGATGTCGACGCAGGACGGGTCATCGATCACCAGGCCGTGCAGGCGTGGGCTGAGAGTCTTGGTGCCGACAAG
CCACTGCCGGTGCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A807AIF1

Antitoxin

Source ID Structure
AlphaFold DB A0A807AK59

References