Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1004615..1005150 Replicon chromosome
Accession NZ_CP015062
Organism Mesorhizobium ciceri strain CC1192

Toxin (Protein)


Gene name relE Uniprot ID E8THD9
Locus tag A4R28_RS04680 Protein ID WP_013532246.1
Coordinates 1004875..1005150 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E8THE0
Locus tag A4R28_RS04675 Protein ID WP_013532247.1
Coordinates 1004615..1004875 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A4R28_RS04650 1000111..1001424 + 1314 WP_013532252.1 serine hydroxymethyltransferase -
A4R28_RS04655 1001501..1002166 + 666 WP_024504683.1 hypothetical protein -
A4R28_RS04660 1002324..1002803 + 480 WP_013532250.1 transcriptional regulator NrdR -
A4R28_RS04665 1002806..1003921 + 1116 WP_063167764.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
A4R28_RS04670 1003934..1004551 + 618 WP_063167765.1 riboflavin synthase -
A4R28_RS04675 1004615..1004875 + 261 WP_013532247.1 ribbon-helix-helix domain-containing protein Antitoxin
A4R28_RS04680 1004875..1005150 + 276 WP_013532246.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A4R28_RS04685 1005232..1005726 + 495 WP_063167766.1 6,7-dimethyl-8-ribityllumazine synthase -
A4R28_RS04690 1005723..1006223 + 501 WP_013532244.1 transcription antitermination factor NusB -
A4R28_RS04695 1006220..1007431 + 1212 WP_063167767.1 MFS transporter -
A4R28_RS04700 1007440..1008012 - 573 WP_013532242.1 NAD(P)H-dependent oxidoreductase -
A4R28_RS04705 1008217..1009128 + 912 WP_013532241.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10616.20 Da        Isoelectric Point: 8.5620

>T62153 WP_013532246.1 NZ_CP015062:1004875-1005150 [Mesorhizobium ciceri]
MELKWTNKALSDLVRLHDFLVLANGPAAARAVQSLTAAPARLVEYPRIGERLEEFEPREVRRILVGSYEIRYEIQNTTIS
VLRLWHTREDR

Download         Length: 276 bp

>T62153 NZ_CP015062:1004875-1005150 [Mesorhizobium ciceri]
ATGGAGTTGAAATGGACCAACAAGGCTTTGTCCGACTTGGTCCGGCTACATGATTTTCTCGTGCTAGCAAATGGCCCGGC
GGCCGCACGTGCCGTGCAGTCGCTTACTGCCGCGCCGGCACGGTTGGTCGAATATCCGCGCATCGGTGAGAGACTGGAAG
AGTTCGAACCACGAGAAGTGCGTCGCATTTTGGTAGGCAGCTACGAAATTCGTTACGAGATACAGAACACGACAATTTCT
GTGTTGCGCCTGTGGCATACGCGAGAGGATCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9646.11 Da        Isoelectric Point: 5.6994

>AT62153 WP_013532247.1 NZ_CP015062:1004615-1004875 [Mesorhizobium ciceri]
MDTKVITAHVPLPLAEKVDQLAARLERPRGWIVKQALSAWVDLEEERRRLTLEAMADVDAGRVIDHQAVQAWAESLGTDK
PLPVPR

Download         Length: 261 bp

>AT62153 NZ_CP015062:1004615-1004875 [Mesorhizobium ciceri]
ATGGATACAAAAGTAATCACCGCTCACGTTCCGCTGCCGCTGGCTGAAAAGGTAGATCAACTGGCTGCCCGCCTTGAGCG
CCCACGCGGCTGGATCGTCAAACAAGCTCTTTCCGCGTGGGTGGATTTGGAGGAGGAGCGCCGACGGCTCACGCTTGAAG
CAATGGCCGATGTCGACGCAGGACGGGTCATCGATCACCAGGCCGTGCAGGCGTGGGCTGAGAGTCTTGGTACCGACAAG
CCACTGCCGGTGCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S2Q9F8

Antitoxin

Source ID Structure
AlphaFold DB A0A436MZK2

References