Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 24670..25297 Replicon plasmid pRGUI02
Accession NZ_CP015041
Organism Rhodovulum sp. P5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RGUI_RS20360 Protein ID WP_172841229.1
Coordinates 24670..25071 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RGUI_RS20365 Protein ID WP_081536305.1
Coordinates 25064..25297 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RGUI_RS21615 21121..21441 + 321 WP_156883121.1 hypothetical protein -
RGUI_RS20340 21738..22496 - 759 WP_081536341.1 hypothetical protein -
RGUI_RS20345 22615..22959 - 345 WP_081536302.1 helix-turn-helix transcriptional regulator -
RGUI_RS20350 22971..23222 - 252 WP_081536303.1 type II toxin-antitoxin system RelE/ParE family toxin -
RGUI_RS20355 23542..24514 - 973 Protein_21 IS5 family transposase -
RGUI_RS20360 24670..25071 - 402 WP_172841229.1 PIN domain-containing protein Toxin
RGUI_RS20365 25064..25297 - 234 WP_081536305.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
RGUI_RS20370 25606..26808 - 1203 Protein_24 Tn3 family transposase -
RGUI_RS21810 26731..27105 + 375 WP_172841227.1 hypothetical protein -
RGUI_RS20375 27209..27616 - 408 WP_081536306.1 hypothetical protein -
RGUI_RS20380 27622..28014 + 393 WP_081536307.1 hypothetical protein -
RGUI_RS20385 28042..29403 - 1362 WP_081536293.1 IS5 family transposase -
RGUI_RS20390 29507..29728 + 222 WP_081536308.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..67286 67286
- inside IScluster/Tn - - 23939..29403 5464


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-114)

Antitoxin

SpoVT-AbrB domain

(5-34)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14531.63 Da        Isoelectric Point: 4.5984

>T62151 WP_172841229.1 NZ_CP015041:c25071-24670 [Rhodovulum sp. P5]
VTDRFFDTNVLLYLLSPDRRKAEIARTLVARGGTISVQVLGELTNVARRKAGLEIDEIAALTGTLRDLLDVVPMTEEIFD
GALQVARQTGYATFDCLIVSAALSSGARSLYTEDMQAGREIGGLKLINPFEER

Download         Length: 402 bp

>T62151 NZ_CP015041:c25071-24670 [Rhodovulum sp. P5]
GTGACTGACAGGTTCTTCGACACGAATGTCCTGCTCTACCTGTTGTCGCCGGATCGGAGGAAGGCCGAGATCGCCCGTAC
ACTTGTCGCCCGGGGCGGCACGATCAGCGTTCAGGTCCTTGGTGAGCTCACAAATGTTGCCCGTCGCAAGGCGGGCCTCG
AAATCGACGAAATCGCGGCGCTGACCGGCACGCTTCGCGATCTCCTCGACGTTGTCCCCATGACGGAGGAGATTTTCGAC
GGTGCGTTGCAGGTGGCGCGGCAGACGGGCTACGCGACCTTCGACTGCCTCATCGTTTCGGCCGCTTTGAGCTCCGGCGC
TCGTTCGCTCTATACCGAAGATATGCAGGCTGGCCGCGAGATCGGTGGGCTGAAGCTGATCAACCCTTTTGAAGAAAGGT
AA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8598.75 Da        Isoelectric Point: 6.3256

>AT62151 WP_081536305.1 NZ_CP015041:c25297-25064 [Rhodovulum sp. P5]
MQVSKWGNSLAVRLPADLVKALDLKEGDDIEIQLADARTFGIARKAGREDLVNRLKAFAGRLPADFRFDREDANARD

Download         Length: 234 bp

>AT62151 NZ_CP015041:c25297-25064 [Rhodovulum sp. P5]
ATGCAGGTTTCCAAATGGGGGAACTCGCTCGCCGTGCGGTTGCCCGCCGATCTGGTCAAGGCGCTCGACCTCAAGGAAGG
CGACGATATCGAGATTCAGCTTGCTGACGCCCGAACCTTTGGCATCGCGCGAAAAGCCGGCCGCGAAGACCTGGTGAACC
GCCTCAAGGCCTTCGCCGGTCGTCTGCCGGCAGATTTCCGGTTCGATCGCGAAGACGCCAACGCGCGTGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References