Detailed information of TA system TA062147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 5782164..5782801
• Replicon: chromosome
• Accession: NZ_CP015036
• Organism: Burkholderia cenocepacia strain 895

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A3203_RS26070
• Protein ID: WP_058902008.1
• Coordinates: 5782164..5782565 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A364GPY9
• Locus tag: A3203_RS26075
• Protein ID: WP_034201144.1
• Coordinates: 5782565..5782801 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A3203_RS26060	5779536..5780678	+	1143	WP_062911464.1	alginate lyase family protein	-
A3203_RS26065	5780709..5782097	+	1389	WP_006485681.1	L-serine ammonia-lyase	-
A3203_RS26070	5782164..5782565	-	402	WP_058902008.1	type II toxin-antitoxin system VapC family toxin	Toxin
A3203_RS26075	5782565..5782801	-	237	WP_034201144.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
A3203_RS26080	5782919..5783148	-	230	Protein_5262	type II toxin-antitoxin system RelE/ParE family toxin	-
A3203_RS26085	5783517..5785220	+	1704	WP_059721116.1	thiamine pyrophosphate-binding protein	-
A3203_RS26090	5785217..5786314	+	1098	WP_062884188.1	hypothetical protein	-
A3203_RS26095	5786409..5787425	-	1017	WP_006493582.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15043.22 Da
• Isoelectric Point: 5.6634

>T62147 WP_058902008.1 NZ_CP015036:c5782565-5782164 [Burkholderia cenocepacia]
MPRFMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGLTACANPARERRHLAALIEDIPVAPFDAAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T62147 NZ_CP015036:c5782565-5782164 [Burkholderia cenocepacia]
ATGCCGCGCTTCATGCTCGACACCAACATGTGTATCTATCTGATGAAAAATCAGCCTGAGCAGGTCGCGAGACGGTTTGC
GCAGTGCTACACGGGCGACGTCGTCATGTCGGCGATCACCTATGCGGAGCTCGAGTACGGCCTGACCGCTTGTGCGAATC
CCGCGCGGGAGCGCCGCCATCTCGCCGCATTGATCGAGGATATTCCCGTCGCGCCTTTCGACGCGGCGGCCGCGCAAGCG
TATGGCCCGGTTCGCGAGGCCACCCGCGAGCGGAAGAAGGATCACCTCGACAAACTGATTGCCGCGCATGCGGTGTCGCT
CGATGTCGTCCTTGTCACCAACAACGAGCGCGATTTCGTCAGCTATCCGGGATTGCGACTGGAGAACTGGCTGAACGACT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8982.15 Da
• Isoelectric Point: 6.4701

>AT62147 WP_034201144.1 NZ_CP015036:c5782801-5782565 [Burkholderia cenocepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMADGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT62147 NZ_CP015036:c5782801-5782565 [Burkholderia cenocepacia]
ATGCATACCACGAGGGTATTCAGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCGGACCTTGCCTATGAGCGCAGCGA
TATCGAACTGGAAATTGAGCGCGTCGGTGACGAAATCCGCATTCGGCCGATGCGGCGGCCTTTGACCCAGGTACTGGCGA
AGTTCGCGAAATTCGGACCGGACTTCATGGCCGATGGGCGTGGCGACCACGAGCAGGCCGAACGTGAGGGTTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A364GPY9