Detailed information of TA system TA062143

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2532253..2532892
• Replicon: chromosome
• Accession: NZ_CP015036
• Organism: Burkholderia cenocepacia strain 895

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A3203_RS11165
• Protein ID: WP_171984202.1
• Coordinates: 2532476..2532892 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A364H554
• Locus tag: A3203_RS11160
• Protein ID: WP_006481537.1
• Coordinates: 2532253..2532489 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A3203_RS11145	2528424..2529197	+	774	WP_058903177.1	SDR family oxidoreductase	-
A3203_RS11150	2529846..2530523	+	678	WP_077175688.1	hypothetical protein	-
A3203_RS11155	2530534..2531760	-	1227	WP_058903176.1	acyltransferase	-
A3203_RS11160	2532253..2532489	+	237	WP_006481537.1	DNA-binding protein	Antitoxin
A3203_RS11165	2532476..2532892	+	417	WP_171984202.1	PIN domain-containing protein	Toxin
A3203_RS11170	2533152..2534048	+	897	WP_058903174.1	VOC family protein	-
A3203_RS11175	2534058..2534951	+	894	WP_048988182.1	CoA transferase subunit A	-
A3203_RS11180	2534962..2535759	+	798	WP_006481539.1	hypothetical protein	-
A3203_RS11185	2535768..2536688	+	921	WP_006481536.1	enoyl-CoA hydratase	-
A3203_RS11190	2536685..2537785	+	1101	WP_058903172.1	nitronate monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15390.58 Da
• Isoelectric Point: 6.8818

>T62143 WP_171984202.1 NZ_CP015036:2532476-2532892 [Burkholderia cenocepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALTNDLTVVTRNVDDFARTGVRLLNPFE

Nucleotide

• Length: 417 bp

>T62143 NZ_CP015036:2532476-2532892 [Burkholderia cenocepacia]
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGCGGGCGTTCTTCAG
GCAGGCCGAAGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGTTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCCTGGCTGACGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCGTTGACCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.78 Da
• Isoelectric Point: 5.0916

>AT62143 WP_006481537.1 NZ_CP015036:2532253-2532489 [Burkholderia cenocepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT62143 NZ_CP015036:2532253-2532489 [Burkholderia cenocepacia]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCGGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAGGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGTGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A364H554