Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2221051..2222843 Replicon chromosome
Accession NZ_CP015036
Organism Burkholderia cenocepacia strain 895

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag A3203_RS09805 Protein ID WP_062910412.1
Coordinates 2221051..2221947 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A364H4C6
Locus tag A3203_RS09810 Protein ID WP_006496928.1
Coordinates 2221986..2222843 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3203_RS09775 2216428..2217507 - 1080 WP_006489902.1 porin -
A3203_RS09780 2217952..2218269 + 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
A3203_RS09785 2218271..2218582 + 312 WP_058903254.1 hypothetical protein -
A3203_RS09790 2218637..2219707 + 1071 WP_062884813.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
A3203_RS09795 2219700..2220470 + 771 WP_006489881.1 SDR family oxidoreductase -
A3203_RS09800 2220505..2221032 + 528 WP_006489904.1 cupin domain-containing protein -
A3203_RS09805 2221051..2221947 + 897 WP_062910412.1 alpha/beta fold hydrolase Toxin
A3203_RS09810 2221986..2222843 + 858 WP_006496928.1 IclR family transcriptional regulator Antitoxin
A3203_RS09815 2222840..2223637 + 798 WP_006496929.1 SDR family oxidoreductase -
A3203_RS09820 2223630..2225297 + 1668 WP_062910413.1 thiamine pyrophosphate-binding protein -
A3203_RS09825 2225290..2226117 + 828 WP_034202181.1 aspartate dehydrogenase -
A3203_RS09830 2226190..2227680 + 1491 WP_062910414.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30585.79 Da        Isoelectric Point: 7.7327

>T62142 WP_062910412.1 NZ_CP015036:2221051-2221947 [Burkholderia cenocepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLIGHSLGAIIAGGLARVTPARIAGLLLVSPAGGYGSAPAETR
EARRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDSFCRQCDTQWGLA

Download         Length: 897 bp

>T62142 NZ_CP015036:2221051-2221947 [Burkholderia cenocepacia]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCGTCGTGGGTCCGCCAGCTCGACACGCTGGGCGCGTCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCAGCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTCCTGATCGGCCATTCGCTCGGCGCGATCATCGCGGGCGGTCTCGCCC
GCGTGACGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAGACCCGC
GAAGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCACGGGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTCCGGGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
GGCAGGGCACGCCGGCTATGTGGAAGCGCCGGCCGCGTATTCCGCGCTGATCGACTCGTTCTGCCGGCAGTGCGATACGC
AGTGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31371.86 Da        Isoelectric Point: 6.5061

>AT62142 WP_006496928.1 NZ_CP015036:2221986-2222843 [Burkholderia cenocepacia]
MSEPLQQNESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGVLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT62142 NZ_CP015036:2221986-2222843 [Burkholderia cenocepacia]
ATGAGCGAACCGCTGCAACAAAACGAATCCGAAAACGCGAAGGCCGAAGCCAGCTACGTGGTGCCGGGCCTCGAACGCGG
GTTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCTGAACTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAACGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCGGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
AAGCCTGCGCGATGCGACAGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGTTCGATCCGCGTGAACGTCGGCACCCGGCTGCCCGCGCATGCAACGACACACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTGTATCCGGAAGGCGTGCTGAACCGGATGACGAGCGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCTTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGATGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTGAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A364H4C6

References