Detailed information of TA system TA062139

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2947809..2948448
• Replicon: chromosome
• Accession: NZ_CP015034
• Organism: Burkholderia cenocepacia strain 842

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A2T82_RS30090
• Protein ID: WP_006481544.1
• Coordinates: 2947809..2948225 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A364H554
• Locus tag: A2T82_RS30095
• Protein ID: WP_006481537.1
• Coordinates: 2948212..2948448 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A2T82_RS30065	2942916..2944016	-	1101	WP_062885552.1	nitronate monooxygenase	-
A2T82_RS30070	2944013..2944933	-	921	WP_006481536.1	enoyl-CoA hydratase	-
A2T82_RS30075	2944942..2945739	-	798	WP_062885554.1	hypothetical protein	-
A2T82_RS30080	2945750..2946643	-	894	WP_062885556.1	CoA transferase subunit A	-
A2T82_RS30085	2946653..2947549	-	897	WP_058903174.1	VOC family protein	-
A2T82_RS30090	2947809..2948225	-	417	WP_006481544.1	type II toxin-antitoxin system VapC family toxin	Toxin
A2T82_RS30095	2948212..2948448	-	237	WP_006481537.1	DNA-binding protein	Antitoxin
A2T82_RS30100	2948941..2950167	+	1227	WP_062885558.1	acyltransferase	-
A2T82_RS30105	2950178..2950855	-	678	WP_077176171.1	hypothetical protein	-
A2T82_RS30110	2951503..2952276	-	774	WP_048988174.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15402.64 Da
• Isoelectric Point: 6.8818

>T62139 WP_006481544.1 NZ_CP015034:c2948225-2947809 [Burkholderia cenocepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Nucleotide

• Length: 417 bp

>T62139 NZ_CP015034:c2948225-2947809 [Burkholderia cenocepacia]
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGCGGGCGTTCTTCAG
GCAGGCCGAAGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCCTGGCTGACGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCATTGATCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.78 Da
• Isoelectric Point: 5.0916

>AT62139 WP_006481537.1 NZ_CP015034:c2948448-2948212 [Burkholderia cenocepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT62139 NZ_CP015034:c2948448-2948212 [Burkholderia cenocepacia]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A364H554