Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2427754..2428400 Replicon chromosome
Accession NZ_CP015034
Organism Burkholderia cenocepacia strain 842

Toxin (Protein)


Gene name vapC Uniprot ID A0A1V2W4R9
Locus tag A2T82_RS27850 Protein ID WP_062885461.1
Coordinates 2427993..2428400 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B4EGU8
Locus tag A2T82_RS27845 Protein ID WP_006491146.1
Coordinates 2427754..2427996 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2T82_RS27830 2423749..2425155 + 1407 WP_006491136.1 aspartate ammonia-lyase -
A2T82_RS27835 2425233..2426738 + 1506 WP_062885459.1 amino acid permease -
A2T82_RS27840 2426812..2427495 - 684 WP_062885460.1 phospholipase -
A2T82_RS27845 2427754..2427996 + 243 WP_006491146.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A2T82_RS27850 2427993..2428400 + 408 WP_062885461.1 type II toxin-antitoxin system VapC family toxin Toxin
A2T82_RS37850 2428516..2428743 - 228 WP_077021721.1 hypothetical protein -
A2T82_RS27855 2428801..2431176 + 2376 WP_034202502.1 MCP four helix bundle domain-containing protein -
A2T82_RS27860 2431199..2431927 + 729 WP_058903588.1 chemotaxis protein -
A2T82_RS27865 2431924..2432505 + 582 WP_058902967.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14936.05 Da        Isoelectric Point: 6.2179

>T62138 WP_062885461.1 NZ_CP015034:2427993-2428400 [Burkholderia cenocepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHELYYGAYKSQRAAANVARVDALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLVTHNVREFERVPRLQFEDWLAEPRAD

Download         Length: 408 bp

>T62138 NZ_CP015034:2427993-2428400 [Burkholderia cenocepacia]
ATGAAGTTCCTCCTGGATACCAACGCGGTGATCGCCATTCTCAAAGGCGAGCCGGCGATACTGGCCCGTTTGCATGCCTG
GCACCCGGCCGATTTCGGGATCCCCGCGATCGTCGCGCACGAGCTTTACTACGGCGCGTACAAGAGCCAGCGAGCGGCTG
CGAACGTCGCGCGTGTCGACGCGCTGCAGTTCGAGGTCGTATCGTTCGACACCGAGGATGCACAGCATGCGGGTGAAATT
CGTGCGCACCTGATCGCGGCCGGCACGCCGATCGGTCCATACGATGCATTGATCGCAGGGCAGGCGCGCGCGCGGCAACT
GGTGCTGGTCACGCACAACGTTCGCGAATTCGAGCGCGTTCCGCGGCTGCAATTCGAAGACTGGCTAGCCGAACCGAGGG
CAGACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.02 Da        Isoelectric Point: 5.0197

>AT62138 WP_006491146.1 NZ_CP015034:2427754-2427996 [Burkholderia cenocepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Download         Length: 243 bp

>AT62138 NZ_CP015034:2427754-2427996 [Burkholderia cenocepacia]
ATGGATACTGCAAAGCTCTTCAAGCATGGTGGCTCGCAGGCTGTCCGGCTGCCGAAGGATTTCCGCTTCGATACGGCCGA
GGTTCGCATCCGCCGCCACGGGGCGGCCGTCATTCTCGAGCCGATGCCGCAAGACTGGGCTTGGCTGGCACCGCTGATCG
GTCCAGTGGACGCCGATTTCGAGGCTGCCGCGACCACACAGCCGTCCGCTCAGGAGCGCTCGGGCCTGGACGTGTTCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V2W4R9

Antitoxin

Source ID Structure
AlphaFold DB B4EGU8

References