Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2630311..2630845 Replicon chromosome
Accession NZ_CP015033
Organism Burkholderia cenocepacia strain 842

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag A2T82_RS13190 Protein ID WP_021033200.1
Coordinates 2630311..2630610 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag A2T82_RS36955 Protein ID WP_021033199.1
Coordinates 2630600..2630845 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2T82_RS13170 2627152..2627901 + 750 WP_058902267.1 uroporphyrinogen-III C-methyltransferase -
A2T82_RS13175 2627898..2628275 + 378 WP_006496449.1 cobalamin biosynthesis protein -
A2T82_RS13180 2628311..2628913 + 603 WP_006476035.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
A2T82_RS13185 2628916..2630220 + 1305 WP_062884537.1 cobyrinate a,c-diamide synthase -
A2T82_RS13190 2630311..2630610 - 300 WP_021033200.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A2T82_RS36955 2630600..2630845 - 246 WP_021033199.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
A2T82_RS13195 2630960..2632123 - 1164 WP_006486051.1 amidohydrolase -
A2T82_RS13200 2632281..2633297 - 1017 WP_062884773.1 acetyltransferase -
A2T82_RS13205 2633297..2634136 - 840 WP_034201792.1 N(5)-hydroxyornithine transformylase PvdF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11720.37 Da        Isoelectric Point: 6.9677

>T62134 WP_021033200.1 NZ_CP015033:c2630610-2630311 [Burkholderia cenocepacia]
MAVKGRQLRLTPLAECDLEDIWRYTAEHWSPEQAEHYYRDLIGTMEALARGKKAGRICVVRDGYFRYPAGSHVVFYRETD
ETIDVIRVLHQRMDIERHL

Download         Length: 300 bp

>T62134 NZ_CP015033:c2630610-2630311 [Burkholderia cenocepacia]
ATGGCGGTTAAAGGCAGACAACTTCGGCTGACCCCGTTGGCTGAATGCGATCTTGAAGACATTTGGCGCTATACCGCCGA
GCATTGGTCGCCTGAGCAGGCAGAGCACTATTACCGCGATCTGATTGGCACCATGGAAGCGCTGGCGCGCGGCAAAAAAG
CGGGGCGGATTTGCGTTGTTCGCGACGGATATTTTCGCTACCCCGCTGGTTCTCACGTTGTGTTCTATCGCGAAACGGAT
GAAACCATCGACGTCATCCGTGTCCTGCATCAACGGATGGACATCGAACGACATCTGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8708.68 Da        Isoelectric Point: 7.3196

>AT62134 WP_021033199.1 NZ_CP015033:c2630845-2630600 [Burkholderia cenocepacia]
MSRNTSVSLGDHFAEFVDAQVRSGRYGSASDVVRAGLRLLESHETQMRALQEALKAGEGSGTPKPFDSEAFLARMRATHG
G

Download         Length: 246 bp

>AT62134 NZ_CP015033:c2630845-2630600 [Burkholderia cenocepacia]
ATGTCGCGAAACACATCCGTTTCCCTTGGCGATCACTTTGCAGAATTTGTCGATGCGCAGGTGCGATCGGGACGATATGG
TTCCGCAAGTGACGTCGTGCGAGCCGGGTTGCGGCTCCTCGAATCACACGAAACGCAAATGCGTGCATTGCAGGAAGCAT
TGAAGGCGGGTGAAGGGTCGGGGACGCCCAAGCCCTTCGACAGCGAGGCCTTCCTGGCCCGCATGCGGGCCACGCATGGC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References