Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4484904..4485561 Replicon chromosome
Accession NZ_CP015025
Organism Klebsiella pneumoniae strain Kpn223

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag WM91_RS22240 Protein ID WP_002916310.1
Coordinates 4484904..4485314 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag WM91_RS22245 Protein ID WP_002916312.1
Coordinates 4485295..4485561 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM91_RS22220 4480904..4482637 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
WM91_RS22225 4482643..4483356 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
WM91_RS22230 4483379..4484275 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
WM91_RS22235 4484376..4484897 + 522 WP_004144730.1 flavodoxin FldB -
WM91_RS22240 4484904..4485314 - 411 WP_002916310.1 protein YgfX Toxin
WM91_RS22245 4485295..4485561 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
WM91_RS22250 4485807..4486790 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
WM91_RS22255 4486941..4487600 - 660 WP_002916317.1 hemolysin III family protein -
WM91_RS22260 4487764..4488075 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
WM91_RS22265 4488125..4488853 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
WM91_RS22270 4488972..4490405 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T62125 WP_002916310.1 NZ_CP015025:c4485314-4484904 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T62125 NZ_CP015025:c4485314-4484904 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT62125 WP_002916312.1 NZ_CP015025:c4485561-4485295 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT62125 NZ_CP015025:c4485561-4485295 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References