Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3866759..3867402 Replicon chromosome
Accession NZ_CP015025
Organism Klebsiella pneumoniae strain Kpn223

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag WM91_RS19185 Protein ID WP_032433387.1
Coordinates 3866759..3867175 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag WM91_RS19190 Protein ID WP_001261276.1
Coordinates 3867172..3867402 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WM91_RS19155 3861928..3862131 - 204 WP_032433376.1 hemolysin expression modulator Hha -
WM91_RS19160 3862191..3862682 - 492 WP_032433378.1 hypothetical protein -
WM91_RS19165 3862713..3863231 - 519 WP_045326794.1 hypothetical protein -
WM91_RS19170 3863290..3863538 - 249 WP_032433382.1 hypothetical protein -
WM91_RS19175 3863857..3865428 + 1572 WP_032433383.1 ATP-binding protein -
WM91_RS19180 3865623..3866603 - 981 WP_032433385.1 hypothetical protein -
WM91_RS19185 3866759..3867175 - 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
WM91_RS19190 3867172..3867402 - 231 WP_001261276.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
WM91_RS19195 3867707..3868522 + 816 WP_032433388.1 hypothetical protein -
WM91_RS19205 3869050..3871290 - 2241 WP_045326788.1 NTPase -
WM91_RS19210 3871293..3872380 - 1088 Protein_3682 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T62124 WP_032433387.1 NZ_CP015025:c3867175-3866759 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T62124 NZ_CP015025:c3867175-3866759 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT62124 WP_001261276.1 NZ_CP015025:c3867402-3867172 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT62124 NZ_CP015025:c3867402-3867172 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References