Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 4711752..4712230 Replicon chromosome
Accession NZ_CP015023
Organism Escherichia coli strain SRCC 1675

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag AR439_RS24130 Protein ID WP_001303876.1
Coordinates 4711752..4712039 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag AR439_RS24135 Protein ID WP_000536233.1
Coordinates 4712039..4712230 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR439_RS24095 4706901..4709372 - 2472 WP_000034474.1 exonuclease -
AR439_RS24100 4709466..4709657 - 192 WP_001098307.1 DUF1482 family protein -
AR439_RS32020 4709654..4709842 - 189 WP_000413705.1 cell division inhibition protein DicB -
AR439_RS24115 4710416..4710601 + 186 WP_001133046.1 hypothetical protein -
AR439_RS24120 4710788..4711177 - 390 WP_000394511.1 hypothetical protein -
AR439_RS24125 4711319..4711474 - 156 WP_000379575.1 DUF1391 family protein -
AR439_RS24130 4711752..4712039 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AR439_RS24135 4712039..4712230 - 192 WP_000536233.1 hypothetical protein Antitoxin
AR439_RS24140 4712258..4712659 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
AR439_RS24145 4712768..4713040 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
AR439_RS24150 4713024..4713449 + 426 WP_000693855.1 Rha family transcriptional regulator -
AR439_RS32035 4713656..4714111 - 456 WP_000273724.1 hypothetical protein -
AR439_RS24160 4714190..4715281 + 1092 WP_001205823.1 hypothetical protein -
AR439_RS24165 4715288..4716034 + 747 WP_000788751.1 ATP-binding protein -
AR439_RS24170 4716056..4716826 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T62103 WP_001303876.1 NZ_CP015023:c4712039-4711752 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T62103 NZ_CP015023:c4712039-4711752 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT62103 WP_000536233.1 NZ_CP015023:c4712230-4712039 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT62103 NZ_CP015023:c4712230-4712039 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References