Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 4935081..4935559 Replicon chromosome
Accession NZ_CP015020
Organism Escherichia coli strain 28RC1

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ARC77_RS24885 Protein ID WP_001303876.1
Coordinates 4935081..4935368 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ARC77_RS24890 Protein ID WP_000536233.1
Coordinates 4935368..4935559 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ARC77_RS24850 4930230..4932701 - 2472 WP_000034474.1 exonuclease -
ARC77_RS24855 4932795..4932986 - 192 WP_001098307.1 DUF1482 family protein -
ARC77_RS32060 4932983..4933171 - 189 WP_000413705.1 cell division inhibition protein DicB -
ARC77_RS24870 4933745..4933930 + 186 WP_001133046.1 hypothetical protein -
ARC77_RS24875 4934117..4934506 - 390 WP_000394511.1 hypothetical protein -
ARC77_RS24880 4934648..4934803 - 156 WP_000379575.1 DUF1391 family protein -
ARC77_RS24885 4935081..4935368 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ARC77_RS24890 4935368..4935559 - 192 WP_000536233.1 hypothetical protein Antitoxin
ARC77_RS24895 4935587..4935988 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ARC77_RS24900 4936097..4936369 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ARC77_RS24905 4936353..4936778 + 426 WP_000693855.1 Rha family transcriptional regulator -
ARC77_RS32075 4936985..4937440 - 456 WP_000273724.1 hypothetical protein -
ARC77_RS24915 4937519..4938604 + 1086 WP_072141648.1 DNA-binding protein -
ARC77_RS24920 4938611..4939357 + 747 WP_000788745.1 ATP-binding protein -
ARC77_RS24925 4939379..4940149 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T62065 WP_001303876.1 NZ_CP015020:c4935368-4935081 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T62065 NZ_CP015020:c4935368-4935081 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT62065 WP_000536233.1 NZ_CP015020:c4935559-4935368 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT62065 NZ_CP015020:c4935559-4935368 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References