Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 323568..324039 | Replicon | chromosome |
Accession | NZ_CP015020 | ||
Organism | Escherichia coli strain 28RC1 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
Locus tag | ARC77_RS01680 | Protein ID | WP_001303511.1 |
Coordinates | 323568..323846 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | Q8XAD5 |
Locus tag | ARC77_RS01685 | Protein ID | WP_001302048.1 |
Coordinates | 323848..324039 (-) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ARC77_RS32355 | 318575..318759 | - | 185 | Protein_317 | DUF3596 domain-containing protein | - |
ARC77_RS01645 | 318794..319045 | - | 252 | WP_000005552.1 | excisionase family protein | - |
ARC77_RS01650 | 319118..321589 | - | 2472 | WP_000048458.1 | exonuclease | - |
ARC77_RS01655 | 321682..321873 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
ARC77_RS01660 | 321870..322058 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
ARC77_RS01665 | 322627..322845 | - | 219 | WP_001171930.1 | hypothetical protein | - |
ARC77_RS01670 | 322917..323216 | - | 300 | WP_001240334.1 | hypothetical protein | - |
ARC77_RS01680 | 323568..323846 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
ARC77_RS01685 | 323848..324039 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
ARC77_RS31385 | 324060..324431 | - | 372 | WP_001169686.1 | hypothetical protein | - |
ARC77_RS01695 | 324529..324831 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
ARC77_RS01700 | 324828..325253 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
ARC77_RS01705 | 325276..326238 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
ARC77_RS01710 | 326245..326985 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
ARC77_RS01720 | 327011..327780 | + | 770 | Protein_331 | DUF1627 domain-containing protein | - |
ARC77_RS01725 | 327796..328155 | + | 360 | WP_062946123.1 | DUF977 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | nleG7' | 316408..416304 | 99896 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T62038 WP_001303511.1 NZ_CP015020:c323846-323568 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T62038 NZ_CP015020:c323846-323568 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT62038 WP_001302048.1 NZ_CP015020:c324039-323848 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT62038 NZ_CP015020:c324039-323848 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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