Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 273829..274428 Replicon chromosome
Accession NZ_CP015018
Organism Polynucleobacter asymbioticus strain Tro8F10W22

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AOC10_RS01465 Protein ID WP_071461707.1
Coordinates 273829..274125 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AOC10_RS01470 Protein ID WP_071461708.1
Coordinates 274126..274428 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOC10_RS01440 269979..270830 - 852 WP_071540254.1 cell envelope integrity protein TolA -
AOC10_RS01445 270855..271274 - 420 WP_011902123.1 protein TolR -
AOC10_RS01450 271284..271940 - 657 WP_071540255.1 protein TolQ -
AOC10_RS01455 272017..273261 + 1245 WP_071540256.1 serine hydroxymethyltransferase -
AOC10_RS01460 273287..273733 + 447 WP_011902126.1 transcriptional regulator NrdR -
AOC10_RS01465 273829..274125 + 297 WP_071461707.1 addiction module killer protein Toxin
AOC10_RS01470 274126..274428 + 303 WP_071461708.1 putative addiction module antidote protein Antitoxin
AOC10_RS01475 274489..275154 - 666 WP_071461709.1 adenylate kinase -
AOC10_RS01480 275258..276022 - 765 WP_071540257.1 3-deoxy-manno-octulosonate cytidylyltransferase -
AOC10_RS01485 276035..276214 - 180 WP_071540566.1 Trm112 family protein -
AOC10_RS01490 276286..277377 - 1092 WP_071540258.1 tetraacyldisaccharide 4'-kinase -
AOC10_RS01495 277398..277847 - 450 WP_081354208.1 biopolymer transporter ExbD -
AOC10_RS01500 277872..278510 - 639 WP_071540259.1 MotA/TolQ/ExbB proton channel family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-93)

Antitoxin

Uncharacterized protein HI1420

(12-98)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11265.26 Da        Isoelectric Point: 10.3903

>T62027 WP_071461707.1 NZ_CP015018:273829-274125 [Polynucleobacter asymbioticus]
MYEIHKTTDFETWLATIRDPLTRGRLFARLRKASLGNLGDVAPISDGVWEMREHFGAGWRMYYMQHRKVVILMLGGGCKS
TQTADIRKVKKLLLLLEG

Download         Length: 297 bp

>T62027 NZ_CP015018:273829-274125 [Polynucleobacter asymbioticus]
ATGTATGAAATCCATAAAACAACTGACTTTGAAACATGGCTTGCAACTATTCGTGATCCGCTAACTCGGGGTAGATTGTT
TGCAAGACTTCGAAAGGCATCTCTAGGGAATCTTGGAGATGTGGCTCCAATTTCTGATGGGGTGTGGGAGATGCGTGAGC
ATTTTGGGGCTGGCTGGAGAATGTATTACATGCAACACAGAAAAGTAGTCATCTTAATGTTGGGTGGTGGCTGTAAATCT
ACACAAACAGCCGATATCAGGAAGGTTAAGAAGTTGCTTCTATTGCTGGAGGGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11113.04 Da        Isoelectric Point: 10.1815

>AT62027 WP_071461708.1 NZ_CP015018:274126-274428 [Polynucleobacter asymbioticus]
MKSSKKIKIKDFPRFDVVDYLKTEKDIAGYLTAVLEDGDPALFVAAIGDIARAKGMTEIAKKSGVTRESLYRALKIEARP
RFETVARVIQALGMKLSVHD

Download         Length: 303 bp

>AT62027 NZ_CP015018:274126-274428 [Polynucleobacter asymbioticus]
ATGAAAAGTAGCAAGAAGATAAAAATAAAAGATTTTCCTAGGTTTGATGTGGTTGATTACTTAAAGACGGAAAAGGATAT
CGCTGGATATCTGACAGCAGTTTTAGAGGATGGAGACCCTGCCTTATTTGTTGCTGCAATTGGTGATATTGCAAGGGCAA
AAGGGATGACCGAGATAGCTAAAAAAAGCGGCGTTACTCGGGAGTCGCTTTATAGAGCTTTAAAAATTGAGGCGAGACCA
CGTTTTGAAACGGTTGCAAGAGTGATACAGGCGCTTGGCATGAAACTTAGCGTTCATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References