Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 646337..646844 Replicon chromosome
Accession NZ_CP015012
Organism Rickettsia amblyommatis isolate An13

Toxin (Protein)


Gene name relB Uniprot ID H8K422
Locus tag A3305_RS03675 Protein ID WP_014391804.1
Coordinates 646581..646844 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID H8K421
Locus tag A3305_RS03670 Protein ID WP_014391803.1
Coordinates 646337..646588 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A3305_RS03640 641504..642571 - 1068 WP_014391798.1 alanine racemase -
A3305_RS03645 642568..643587 - 1020 WP_014391799.1 ribose-phosphate diphosphokinase -
A3305_RS03655 643812..644411 - 600 WP_014391800.1 phospholipid-binding protein MlaC -
A3305_RS03660 644432..645187 - 756 WP_041860557.1 VacJ family lipoprotein -
A3305_RS03665 645192..646196 - 1005 WP_014391802.1 methyltransferase domain-containing protein -
A3305_RS03670 646337..646588 + 252 WP_014391803.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
A3305_RS03675 646581..646844 + 264 WP_014391804.1 Txe/YoeB family addiction module toxin Toxin
A3305_RS03680 646904..648109 + 1206 WP_014391805.1 pyridoxal phosphate-dependent aminotransferase -
A3305_RS03685 648260..648916 + 657 WP_014391806.1 lysophospholipid acyltransferase family protein -
A3305_RS03690 648913..650307 + 1395 WP_045799382.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
A3305_RS03695 650372..650800 - 429 WP_158309380.1 Sca4 family protein -
A3305_RS03700 650914..651318 - 405 Protein_682 hypothetical protein -
A3305_RS08860 651600..651719 - 120 WP_144010744.1 palindromic element RPE4 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10498.35 Da        Isoelectric Point: 9.6904

>T62024 WP_014391804.1 NZ_CP015012:646581-646844 [Rickettsia amblyommatis]
MIEIEWTLEAAEDLACWKKYDIKKYERIKLLIKNIQEAPFIGIGKPEALKHILSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

>T62024 NZ_CP015012:646581-646844 [Rickettsia amblyommatis]
ATGATTGAGATTGAGTGGACACTAGAAGCAGCGGAGGATTTAGCGTGTTGGAAAAAATATGATATTAAAAAATATGAACG
TATTAAACTTCTAATAAAAAATATCCAAGAAGCACCGTTTATAGGTATAGGTAAACCCGAAGCTTTAAAACATATATTAT
CAGGTTTATGGTCACGTAGAATTAACCACGAACATAGACTAATATATTCTGTCAATACTAAACAAATTATAATATATAAT
TGTAGATTTCATTATAAAAATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9521.77 Da        Isoelectric Point: 9.4884

>AT62024 WP_014391803.1 NZ_CP015012:646337-646588 [Rickettsia amblyommatis]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNPANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp

>AT62024 NZ_CP015012:646337-646588 [Rickettsia amblyommatis]
ATGAACTCAATTAGCGGCACTTCATTTAGAAAAAACTTAAGCTCTGTACTAAATACCGTAGAAAACGATCATGTCCCTTA
TCTTATTAAAAGAAAGAATCATAAGAATATTATTCTTTTAACAGAAGAAGAATATGAATCTACAAAAGAAACATTATATT
TATTATCTAATCCGGCTAATGCGAATCGAATAAAAAAATCTATCGAACAAGCAAAAAGAGGAGAGTTTGCTAAAGTTAAT
TTAGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H8K422

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2M0P5

References