Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 78251..79133 Replicon plasmid pAA01
Accession NZ_CP015006
Organism Aminobacter aminovorans strain KCTC 2477

Toxin (Protein)


Gene name - Uniprot ID A0A142MDR5
Locus tag AA2016_RS27870 Protein ID WP_067967360.1
Coordinates 78615..79133 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7W3KUD3
Locus tag AA2016_RS27865 Protein ID WP_067967357.1
Coordinates 78251..78622 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA2016_RS27850 74414..76246 + 1833 WP_067967346.1 ABC transporter ATP-binding protein -
AA2016_RS27855 76429..77382 + 954 WP_067967349.1 DUF1403 family protein -
AA2016_RS27860 77385..78062 + 678 WP_067967354.1 SMC-Scp complex subunit ScpB -
AA2016_RS27865 78251..78622 + 372 WP_067967357.1 DUF2384 domain-containing protein Antitoxin
AA2016_RS27870 78615..79133 + 519 WP_067967360.1 RES domain-containing protein Toxin
AA2016_RS27875 79304..81721 - 2418 WP_067967361.1 EAL domain-containing protein -
AA2016_RS27880 81732..82262 - 531 WP_067967364.1 molybdopterin-dependent oxidoreductase -
AA2016_RS27885 82481..82852 + 372 WP_067968412.1 6-carboxytetrahydropterin synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..534207 534207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-165)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(22-63)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19072.69 Da        Isoelectric Point: 6.4763

>T62023 WP_067967360.1 NZ_CP015006:78615-79133 [Aminobacter aminovorans]
MPEAALRQQRTLWRAFVPRWAHMPLSGEGAARFGGRWNPVGAPTLYAACELSTAWAEYNQGFVQHPALIAQLELSDARLA
DLTVAAILDELGIDAGIHRCEWRSDLDDGRAPQTHLLRQRLLTEGFDGVVYPSFMSPGGSCVALWRWNGPGQPSLKVIDP
DQRLPKTQASWL

Download         Length: 519 bp

>T62023 NZ_CP015006:78615-79133 [Aminobacter aminovorans]
ATGCCTGAAGCCGCCCTGCGTCAGCAGCGGACCTTGTGGCGGGCCTTCGTGCCGCGCTGGGCGCATATGCCGCTTTCGGG
CGAAGGTGCCGCACGTTTCGGCGGGCGATGGAACCCGGTGGGCGCACCGACGCTGTATGCGGCCTGCGAGCTGTCGACGG
CCTGGGCCGAATACAACCAGGGTTTTGTCCAGCATCCGGCGTTGATCGCCCAGCTCGAGCTGTCGGACGCGAGGCTGGCC
GACCTGACTGTTGCCGCGATTTTGGACGAACTCGGCATCGATGCCGGCATTCACAGATGCGAGTGGCGTTCCGATCTCGA
CGACGGCAGGGCACCGCAAACCCATCTGCTGCGGCAGCGCCTGCTCACCGAAGGCTTTGACGGCGTCGTCTATCCCTCGT
TCATGTCTCCCGGCGGCAGTTGCGTAGCATTGTGGCGCTGGAACGGTCCCGGCCAGCCATCACTCAAGGTTATAGATCCT
GATCAGCGCCTGCCCAAGACGCAGGCCTCCTGGCTTTAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13028.98 Da        Isoelectric Point: 10.2736

>AT62023 WP_067967357.1 NZ_CP015006:78251-78622 [Aminobacter aminovorans]
MAAQSLGMSAAHFGEARSQFLSARRVSELLGVTQADLARLVGVARNTLTARSGARKVDQALSPVVRILAMAAEMAGDESR
AAIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAVRSGVYA

Download         Length: 372 bp

>AT62023 NZ_CP015006:78251-78622 [Aminobacter aminovorans]
ATGGCAGCTCAGAGTTTGGGAATGTCGGCGGCCCATTTCGGTGAGGCCCGGTCGCAGTTTCTCTCGGCTCGCCGCGTGTC
GGAACTGCTGGGTGTCACCCAGGCCGACCTGGCCCGGCTCGTTGGCGTTGCCCGCAACACGCTGACGGCGCGCTCCGGAG
CACGCAAGGTCGACCAGGCGCTCAGCCCCGTTGTCCGCATCCTGGCGATGGCCGCCGAGATGGCGGGCGACGAAAGCCGC
GCGGCGATCTGGTTCAAGCATCAGCCCATCCCGGGCTGGGCCGGCAAGACGGCCTATGACCTGGTCGGCGAGGGCAAGGC
GGACAAGGTTCTGGCCTATCTGGAGGCGGTGCGCTCCGGCGTTTATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142MDR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7W3KUD3

References