Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5231481..5233171 Replicon chromosome
Accession NZ_CP015005
Organism Aminobacter aminovorans strain KCTC 2477

Toxin (Protein)


Gene name HipA2 Uniprot ID -
Locus tag AA2016_RS25595 Protein ID WP_154385356.1
Coordinates 5231481..5232830 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name HipB2 Uniprot ID -
Locus tag AA2016_RS33740 Protein ID WP_083948797.1
Coordinates 5232836..5233171 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA2016_RS25565 5226628..5227977 + 1350 WP_067965101.1 P-type conjugative transfer protein TrbL -
AA2016_RS25570 5227974..5228663 + 690 WP_067965102.1 conjugal transfer protein TrbF -
AA2016_RS25575 5228660..5229640 + 981 WP_067965104.1 P-type conjugative transfer protein TrbG -
AA2016_RS25580 5229637..5230785 + 1149 WP_067965106.1 TrbI/VirB10 family protein -
AA2016_RS25585 5230782..5231012 + 231 WP_067965108.1 DUF2274 domain-containing protein -
AA2016_RS33735 5231173..5231430 + 258 WP_083948686.1 AlpA family phage regulatory protein -
AA2016_RS25595 5231481..5232830 - 1350 WP_154385356.1 HipA domain-containing protein Toxin
AA2016_RS33740 5232836..5233171 - 336 WP_083948797.1 helix-turn-helix transcriptional regulator Antitoxin
AA2016_RS25605 5234196..5235452 - 1257 WP_067965111.1 site-specific integrase -
AA2016_RS25610 5235746..5237308 - 1563 WP_067965113.1 glutamine-hydrolyzing GMP synthase -
AA2016_RS25615 5237406..5237864 - 459 WP_067965115.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - katA 5033831..5274777 240946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-106)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 49012.78 Da        Isoelectric Point: 5.5530

>T62022 WP_154385356.1 NZ_CP015005:c5232830-5231481 [Aminobacter aminovorans]
VDLLALDVRLDGFDDPVGVFVRDERGAVAFGYNRRYLANPDAAPLSLSLPLVGGPYPDVAARAFFDNLLQERDGALTEVM
EREGLARDDIAGLLFHLGKDCAGALSVLPMGSPPAKVPGDYERDYVPIPPDRLAAIVEALHNRTRLPTGMEDPSPLAGVQ
SKIALTVLPDGRFAEPNPGSGAPTTHILKVPDQGHKRDARYEAEAMDLSRKLGMETAEATALPVGGIEALLVTRFDRGRD
RLGRVVRLHQEDFAQALGLPASMKYERRGREGRRFDVSGIRKILEQTVDPARAKEAFIQATIFDLLVGNADGHAKNFALL
YEPGGRVRLAPRYDILPTRLDDSLTDELPYSIGEAKTLDEVTPSALDAFFQALGIENAAGRRRLAQRYARDIAFALASHL
KALEKNEKRFADLIASNIRALLGALEIEIPDAARERDAFISKAGGWHMS

Download         Length: 1350 bp

>T62022 NZ_CP015005:c5232830-5231481 [Aminobacter aminovorans]
GTGGATCTTCTTGCCCTTGATGTAAGGCTGGATGGTTTTGATGATCCTGTTGGCGTCTTCGTACGTGACGAAAGGGGTGC
CGTCGCTTTCGGATACAACAGACGCTATCTCGCGAACCCCGATGCCGCCCCCTTATCTTTGTCTCTTCCGCTCGTTGGGG
GGCCTTACCCCGATGTTGCCGCGCGGGCCTTTTTCGACAATCTCCTTCAGGAGCGAGACGGCGCGCTAACGGAAGTGATG
GAGCGAGAGGGGCTTGCCCGAGACGACATCGCTGGCCTGCTGTTTCATCTCGGGAAGGACTGTGCAGGGGCTCTCTCTGT
CCTCCCAATGGGATCGCCGCCTGCCAAGGTTCCGGGCGACTACGAACGGGACTATGTCCCTATACCACCAGACCGGCTCG
CTGCGATTGTCGAGGCACTCCACAATCGCACGCGTTTGCCCACCGGAATGGAGGATCCATCTCCGCTGGCTGGTGTGCAA
AGCAAGATCGCATTGACAGTTCTTCCGGACGGAAGGTTTGCCGAACCGAACCCGGGATCAGGTGCGCCAACAACGCACAT
TCTGAAGGTGCCGGATCAGGGGCATAAGCGTGATGCGCGGTATGAGGCAGAGGCGATGGATCTGTCGCGGAAATTGGGTA
TGGAGACGGCGGAAGCTACAGCGCTTCCGGTTGGGGGAATCGAAGCCCTTCTCGTCACCCGTTTCGACCGCGGGCGAGAT
AGGCTGGGCAGGGTCGTACGCCTGCATCAAGAGGATTTCGCCCAGGCTCTCGGGCTGCCTGCCTCGATGAAGTATGAGCG
GCGAGGGAGGGAAGGCCGTCGTTTTGATGTTTCCGGCATTCGCAAGATACTTGAACAGACCGTTGACCCTGCCCGGGCCA
AGGAAGCCTTCATTCAAGCCACGATATTTGATCTCTTGGTGGGTAATGCCGATGGCCATGCCAAGAATTTCGCTCTCCTT
TACGAGCCGGGCGGCCGTGTCCGCCTGGCGCCGCGCTACGACATTCTGCCCACGCGACTGGACGACAGCCTGACTGACGA
ACTGCCTTACAGCATCGGTGAGGCAAAGACGCTCGACGAAGTTACGCCGAGCGCGCTCGACGCGTTTTTCCAAGCGCTAG
GGATCGAAAACGCTGCGGGACGGAGGCGCCTGGCTCAGCGATACGCGAGAGATATTGCGTTTGCGCTGGCCAGCCATCTG
AAGGCTCTCGAAAAAAATGAGAAGCGCTTCGCAGACTTGATTGCGTCCAACATCAGAGCTTTGCTCGGCGCTTTGGAGAT
AGAAATACCCGACGCGGCCAGGGAGCGGGATGCGTTTATCAGCAAGGCTGGTGGATGGCACATGAGTTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12167.75 Da        Isoelectric Point: 10.7725

>AT62022 WP_083948797.1 NZ_CP015005:c5233171-5232836 [Aminobacter aminovorans]
MPQGVRVSLPHSVQDSYKQQNRATGDDNAIASRAIRDTEAEGLEVVSPSDLGLLVRRARETRHLSQQSFADLAGVGRRFL
SELENGKPTLELGKVLKVARTAGISLFARQR

Download         Length: 336 bp

>AT62022 NZ_CP015005:c5233171-5232836 [Aminobacter aminovorans]
ATGCCGCAAGGTGTACGGGTCTCCCTGCCGCATTCGGTTCAGGATTCGTATAAACAGCAGAATAGGGCGACGGGAGACGA
TAATGCGATCGCGTCGCGGGCTATTCGTGACACGGAAGCGGAAGGGTTGGAGGTGGTCTCTCCTTCAGATCTCGGACTGC
TGGTGCGTCGCGCACGCGAAACCCGCCATCTATCGCAGCAGAGCTTCGCTGACCTGGCGGGTGTCGGGCGCAGGTTTCTG
TCCGAGCTGGAAAACGGCAAGCCGACTCTCGAACTGGGCAAAGTTCTGAAGGTCGCCCGCACGGCCGGCATATCGCTCTT
TGCTCGGCAGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References