Detailed information of TA system TA061976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 39044..39594
• Replicon: plasmid pPA7790
• Accession: NZ_CP015000
• Organism: Pseudomonas aeruginosa strain PA7790

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: PA7790_RS33065
• Protein ID: WP_019727125.1
• Coordinates: 39319..39594 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6B1YL09
• Locus tag: PA7790_RS33060
• Protein ID: WP_019727126.1
• Coordinates: 39044..39319 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PA7790_RS33005	34545..34922	-	378	WP_019727137.1	hypothetical protein	-
PA7790_RS33010	34965..35249	-	285	WP_019727136.1	hypothetical protein	-
PA7790_RS33015	35365..35559	+	195	WP_171978759.1	hypothetical protein	-
PA7790_RS33020	35609..35857	-	249	WP_019727134.1	hypothetical protein	-
PA7790_RS33030	36295..36747	-	453	WP_019727132.1	DNA repair protein RadC	-
PA7790_RS33045	37397..37705	-	309	WP_019727129.1	hypothetical protein	-
PA7790_RS33050	38029..38322	-	294	WP_019727128.1	hypothetical protein	-
PA7790_RS33055	38383..38769	-	387	WP_019727127.1	hypothetical protein	-
PA7790_RS33060	39044..39319	+	276	WP_019727126.1	ribbon-helix-helix domain-containing protein	Antitoxin
PA7790_RS33065	39319..39594	+	276	WP_019727125.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PA7790_RS33070	39685..40101	-	417	WP_019727124.1	hypothetical protein	-
PA7790_RS33075	40469..40789	-	321	WP_019727123.1	hypothetical protein	-
PA7790_RS33080	40993..41181	-	189	WP_019727122.1	hypothetical protein	-
PA7790_RS33085	41271..41465	-	195	WP_019727121.1	hypothetical protein	-
PA7790_RS33090	41895..42086	-	192	WP_003142924.1	hypothetical protein	-
PA7790_RS33095	42161..42427	-	267	WP_019727120.1	hypothetical protein	-
PA7790_RS33100	42466..43536	-	1071	WP_019727119.1	DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..49021	49021

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (11-48)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10779.36 Da
• Isoelectric Point: 7.1659

>T61976 WP_019727125.1 NZ_CP015000:39319-39594 [Pseudomonas aeruginosa]
MELKWTSKGLSDVARLYEFLATVNREAAARTVQQLTSAPTALLTNPRLGERLEEFEPRDVRRILIGHYEMRYEILDSCIY
VLRLWHTREDR

Nucleotide

• Length: 276 bp

>T61976 NZ_CP015000:39319-39594 [Pseudomonas aeruginosa]
ATGGAGTTGAAGTGGACGAGCAAAGGGCTCTCCGACGTGGCACGGCTCTACGAGTTCCTGGCTACGGTGAACAGGGAAGC
TGCCGCCCGCACGGTGCAGCAGCTGACGAGCGCGCCGACCGCCTTGTTGACCAACCCGCGGCTGGGCGAGCGCCTGGAAG
AGTTCGAACCGCGGGATGTTCGCCGCATCCTGATCGGCCACTATGAGATGCGCTATGAGATCCTGGATTCCTGCATCTAC
GTGCTTCGTCTGTGGCACACACGCGAAGACAGGTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10142.32 Da
• Isoelectric Point: 4.8433

>AT61976 WP_019727126.1 NZ_CP015000:39044-39319 [Pseudomonas aeruginosa]
MSTAAKPTRTVTAHVPVDLAERVDAIAERLERSKNWIVRQALSAWIDQEDERSRLTREALDDVDAGRVVDHQAVQAWAES
LGTDSPLPVPR

Nucleotide

• Length: 276 bp

>AT61976 NZ_CP015000:39044-39319 [Pseudomonas aeruginosa]
ATGAGCACAGCAGCCAAACCAACGCGCACCGTGACTGCTCACGTCCCGGTAGATCTGGCCGAGCGCGTCGATGCAATCGC
CGAGCGCCTGGAGCGATCGAAGAACTGGATCGTCAGGCAGGCGCTGTCAGCCTGGATCGACCAGGAAGACGAGCGTAGCC
GTCTGACACGTGAAGCCTTGGATGATGTAGACGCAGGACGTGTCGTCGACCACCAGGCCGTCCAGGCCTGGGCCGAAAGC
CTGGGCACTGACTCTCCGCTGCCGGTACCACGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A6B1YL09