Detailed information of TA system TA061969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 636194..636831
• Replicon: chromosome
• Accession: NZ_CP014999
• Organism: Pseudomonas aeruginosa strain PA7790

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PA7790_RS02950
• Protein ID: WP_019725766.1
• Coordinates: 636194..636376 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PA7790_RS02955
• Protein ID: WP_019725767.1
• Coordinates: 636409..636831 (+)
• Length: 141 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PA7790_RS34490	632074..632362	-	289	Protein_582	DDE-type integrase/transposase/recombinase	-
PA7790_RS33240	632428..633804	+	1377	WP_076611796.1	IS30-like element ISPa37 family transposase	-
PA7790_RS33245	633812..634688	-	877	Protein_584	IS3 family transposase	-
PA7790_RS02945	634753..635617	-	865	Protein_585	site-specific integrase	-
PA7790_RS02950	636194..636376	+	183	WP_019725766.1	type II toxin-antitoxin system HicA family toxin	Toxin
PA7790_RS02955	636409..636831	+	423	WP_019725767.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PA7790_RS02960	637077..638048	-	972	WP_025982283.1	hypothetical protein	-
PA7790_RS02965	638033..638725	-	693	WP_019725770.1	hypothetical protein	-
PA7790_RS02970	638722..639264	-	543	WP_025982284.1	hypothetical protein	-
PA7790_RS02975	639261..640184	-	924	WP_019725772.1	hypothetical protein	-
PA7790_RS02980	640181..640657	-	477	WP_019725773.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	623825..684682	60857

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-62)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6970.07 Da
• Isoelectric Point: 10.2954

>T61969 WP_019725766.1 NZ_CP014999:636194-636376 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Nucleotide

• Length: 183 bp

>T61969 NZ_CP014999:636194-636376 [Pseudomonas aeruginosa]
ATGAAGTACAGCGAGTTTCGGCGCTGGTTGAAGGCTCGGGGAGTCATTTTCGAGCCTGCCAAGGGAAGCCACTTCAAGGT
TTACTACGGCGACAACCAGACGATTTTCCCCGACCATGGAGCCAAGGAAATAGGCGATGGGTTGAGGAAGAAGATAATCA
AAGACCTGGGCCTCAAGGATTGA

Antitoxin

Protein

• Length: 141 a.a.
• Molecular weight: 14970.22 Da
• Isoelectric Point: 4.9047

>AT61969 WP_019725767.1 NZ_CP014999:636409-636831 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Nucleotide

• Length: 423 bp

>AT61969 NZ_CP014999:636409-636831 [Pseudomonas aeruginosa]
ATGTTTGACTATCCCGTAACGGTTCACGAGGAAGCCGGCAGCGTGTGGGTCAGCTGCGACGATGTACCTGAAATGGCGAG
CGCCGGAGATACCGTTGATGAAGCGCTGCTGGACGCTGTGGAAGGCCTAGAGTCGGCCCTGTCGCTCTATGTGGACCGGC
GGCAGTCGATCCCGCTGCCGTCGAAAGGCAAAGCGGGTCAGTCGATCGTTCGATTGCCCGCGCTCACTTCGGCCAAGATT
GCGCTGTGGAACACCATGCTGGCTCAGAACGTAGGGAAGGCGGAACTGGCTCGCCGGCTGGGAGTGAATCGCGTTCAGGT
AGACCGCCTGGTGGATCTGCTCCACGGGTCGAAGATCGAAGCGGTGGAACATGCTCTGGCGATCTTGGGCCAACGGTTGG
CTGTGACTGTCATTGCGGCATAA