Detailed information of TA system TA061966

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 3653..4410
• Replicon: plasmid unnamed
• Accession: NZ_CP014997
• Organism: Salmonella enterica subsp. enterica serovar Weltevreden str. 1655

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: A0A4U8I7M5
• Locus tag: SEEW1655_RS24675
• Protein ID: WP_000406363.1
• Coordinates: 3653..4135 (-)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A4U8I6Z6
• Locus tag: SEEW1655_RS24680
• Protein ID: WP_001195099.1
• Coordinates: 4126..4410 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEW1655_RS24655	695..1453	-	759	WP_000493752.1	4'-phosphopantetheinyl transferase superfamily protein	-
SEEW1655_RS24660	1611..1895	+	285	WP_000537154.1	IS3 family transposase	-
SEEW1655_RS24665	1892..2746	+	855	WP_077905131.1	IS3 family transposase	-
SEEW1655_RS24670	2820..3269	-	450	WP_000750479.1	hypothetical protein	-
SEEW1655_RS24675	3653..4135	-	483	WP_000406363.1	GNAT family N-acetyltransferase	Toxin
SEEW1655_RS24680	4126..4410	-	285	WP_001195099.1	DUF1778 domain-containing protein	Antitoxin
SEEW1655_RS24685	4722..4982	+	261	WP_000929810.1	hypothetical protein	-
SEEW1655_RS24690	4979..5941	+	963	WP_000145248.1	hypothetical protein	-
SEEW1655_RS24695	5926..6204	-	279	WP_000534855.1	cloacin	-
SEEW1655_RS26580	6541..6735	-	195	Protein_10	DUF4158 domain-containing protein	-
SEEW1655_RS24705	7138..8187	-	1050	WP_001534988.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..81966	81966

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (54-91)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 23713.45 Da
• Isoelectric Point: 5.5500

>T61966 WP_000406363.1 NZ_CP014997:c4135-3653 [Salmonella enterica subsp. enterica serovar Weltevreden str. 1655]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
F

Nucleotide

• Length: 483 bp

>T61966 NZ_CP014997:c4135-3653 [Salmonella enterica subsp. enterica serovar Weltevreden str. 1655]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTT

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 13999.79 Da
• Isoelectric Point: 5.5500

>AT61966 WP_001195099.1 NZ_CP014997:c4410-4126 [Salmonella enterica subsp. enterica serovar Weltevreden str. 1655]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFF

Nucleotide

• Length: 285 bp

>AT61966 NZ_CP014997:c4410-4126 [Salmonella enterica subsp. enterica serovar Weltevreden str. 1655]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Structures

Toxin

• AlphaFold DB: A0A4U8I7M5

Antitoxin

• AlphaFold DB: A0A4U8I6Z6