Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3556132..3556823 Replicon chromosome
Accession NZ_CP014989
Organism Serinicoccus hydrothermalis strain JLT9

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B1NGW3
Locus tag SGUI_RS16695 Protein ID WP_066642247.1
Coordinates 3556132..3556572 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B1NGW8
Locus tag SGUI_RS16700 Protein ID WP_066642255.1
Coordinates 3556569..3556823 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SGUI_RS16675 3551325..3552062 - 738 WP_066642238.1 AAA family ATPase -
SGUI_RS16680 3552140..3553321 + 1182 WP_066642241.1 signal recognition particle-docking protein FtsY -
SGUI_RS16685 3553431..3554366 - 936 WP_066642242.1 DUF2236 domain-containing protein -
SGUI_RS16690 3554462..3556102 + 1641 WP_066642245.1 signal recognition particle protein -
SGUI_RS16695 3556132..3556572 - 441 WP_066642247.1 type II toxin-antitoxin system VapC family toxin Toxin
SGUI_RS16700 3556569..3556823 - 255 WP_066642255.1 antitoxin Antitoxin
SGUI_RS16705 3556909..3558054 + 1146 WP_066642257.1 M4 family metallopeptidase -
SGUI_RS16710 3558051..3558635 + 585 WP_066642258.1 mismatch-specific DNA-glycosylase -
SGUI_RS16715 3558668..3559351 - 684 WP_157621898.1 N-acetyltransferase -
SGUI_RS16720 3559423..3560526 + 1104 WP_066642260.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(3-140)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 15557.77 Da        Isoelectric Point: 6.9785

>T61963 WP_066642247.1 NZ_CP014989:c3556572-3556132 [Serinicoccus hydrothermalis]
VKVVDANVLLYAVNPSARHHEASRRWLDGALSGSETVGFSWLVLTAFVRLSTKVGLFPHPLQPGQAIAVVRAWLGAPGAR
MLEPGGAHLTLMESILSEVGSGGNLVSDAHLAAIALEANAGVVSYDTDFSRFERVRCSRPDDLLGR

Download         Length: 441 bp

>T61963 NZ_CP014989:c3556572-3556132 [Serinicoccus hydrothermalis]
GTGAAGGTCGTCGACGCCAACGTCCTCCTCTATGCCGTCAACCCGTCGGCGCGACACCACGAGGCGTCCCGCCGGTGGTT
GGACGGTGCCCTCAGCGGTAGTGAGACGGTCGGGTTCAGCTGGCTGGTGCTCACCGCCTTCGTCCGGCTGTCGACCAAGG
TGGGCCTGTTCCCCCACCCGCTCCAGCCTGGCCAGGCGATCGCGGTCGTGCGTGCCTGGCTGGGCGCTCCCGGGGCGAGG
ATGCTCGAGCCCGGCGGGGCACACCTCACCCTCATGGAGTCGATCCTGAGCGAGGTGGGTAGCGGCGGCAACCTGGTCAG
CGACGCCCACCTCGCCGCCATCGCTCTCGAGGCGAACGCCGGCGTCGTCAGCTATGACACGGACTTCTCACGCTTCGAAC
GGGTGCGCTGCTCCCGACCGGATGACCTCCTCGGTCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9446.60 Da        Isoelectric Point: 5.8376

>AT61963 WP_066642255.1 NZ_CP014989:c3556823-3556569 [Serinicoccus hydrothermalis]
MRTTVTLDPDTESLIRQEMLRRGVSFKRALNDAIRAGSTGRQSPAPFRTQVHDLGEPTVNLDRALQLSGELEDEELIRQV
RTGQ

Download         Length: 255 bp

>AT61963 NZ_CP014989:c3556823-3556569 [Serinicoccus hydrothermalis]
ATGCGCACCACGGTCACGCTCGACCCGGACACGGAGTCCCTGATCCGGCAGGAGATGCTGCGCCGGGGGGTCTCCTTCAA
GCGGGCCCTGAACGACGCCATCCGCGCGGGGAGCACCGGCCGCCAGTCACCCGCGCCCTTCCGCACCCAGGTGCACGACC
TCGGTGAGCCGACGGTGAACCTCGACCGCGCGCTGCAGCTCAGCGGCGAGCTCGAGGACGAAGAACTGATCAGGCAGGTC
AGGACCGGTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1NGW3

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1NGW8

References