Detailed information of TA system TA061962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3124365..3125037
• Replicon: chromosome
• Accession: NZ_CP014989
• Organism: Serinicoccus hydrothermalis strain JLT9

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1B1NFS6
• Locus tag: SGUI_RS14600
• Protein ID: WP_022925264.1
• Coordinates: 3124365..3124802 (-)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1B1NFQ3
• Locus tag: SGUI_RS14605
• Protein ID: WP_066641485.1
• Coordinates: 3124789..3125037 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGUI_RS14575	3119772..3120740	-	969	WP_157621863.1	hypothetical protein	-
SGUI_RS14580	3120782..3121147	-	366	WP_157621864.1	hypothetical protein	-
SGUI_RS14585	3122370..3122816	+	447	WP_066641483.1	MaoC family dehydratase N-terminal domain-containing protein	-
SGUI_RS14590	3122816..3123220	+	405	WP_066641484.1	MaoC family dehydratase N-terminal domain-containing protein	-
SGUI_RS14595	3123286..3124368	+	1083	WP_066643479.1	UDP-N-acetylmuramate dehydrogenase	-
SGUI_RS14600	3124365..3124802	-	438	WP_022925264.1	PIN domain-containing protein	Toxin
SGUI_RS14605	3124789..3125037	-	249	WP_066641485.1	ribbon-helix-helix protein, CopG family	Antitoxin
SGUI_RS14610	3125082..3125363	-	282	WP_066641486.1	alpha/beta-hydrolase family protein	-
SGUI_RS17555	3125409..3126035	-	627	WP_157621866.1	hypothetical protein	-
SGUI_RS14620	3126045..3127091	-	1047	WP_066641490.1	adenosine deaminase	-
SGUI_RS14625	3127140..3127718	+	579	WP_066641492.1	SRPBCC family protein	-
SGUI_RS14630	3127746..3128711	+	966	WP_066641494.1	ABC transporter ATP-binding protein	-
SGUI_RS14635	3128708..3129595	+	888	WP_066641500.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-133)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-39)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15486.70 Da
• Isoelectric Point: 7.1299

>T61962 WP_022925264.1 NZ_CP014989:c3124802-3124365 [Serinicoccus hydrothermalis]
MLALDVNVLVGALHRGSPGHTTLRPWLERAVDGEEVVGISDAVLTGTLRVVTHPRVFTTPATVPEAAASISNLLRHPNVR
TLRTLAGHWQLVLDLCERAGATGNLVADAAHAATAMQHGATLISDDADFARFPGLAWRRPLDPRP

Nucleotide

• Length: 438 bp

>T61962 NZ_CP014989:c3124802-3124365 [Serinicoccus hydrothermalis]
ATGCTCGCCCTTGACGTCAACGTGCTGGTGGGGGCGCTCCACCGGGGCTCACCCGGCCACACGACACTGCGGCCCTGGCT
GGAGCGGGCGGTCGACGGGGAGGAGGTCGTGGGCATCAGCGACGCGGTGCTCACCGGGACCCTGCGCGTCGTGACCCACC
CCCGGGTCTTCACGACCCCTGCGACGGTGCCGGAGGCGGCCGCGTCGATCAGCAACCTGCTGAGACACCCCAACGTGCGC
ACCTTGCGGACGCTGGCGGGGCACTGGCAACTGGTCCTCGACCTGTGCGAGCGGGCCGGCGCCACCGGCAACCTCGTCGC
CGACGCGGCTCACGCGGCCACGGCGATGCAACATGGCGCGACGCTCATCAGTGACGACGCCGACTTCGCCCGGTTCCCCG
GACTGGCCTGGCGCCGCCCGCTGGACCCACGTCCCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9168.23 Da
• Isoelectric Point: 5.1358

>AT61962 WP_066641485.1 NZ_CP014989:c3125037-3124789 [Serinicoccus hydrothermalis]
VRTTIRLPQDLYDEVRETALRERRTVTSLIEESLREALASRSHRRHDAPFSLTPVGGDGGLRPGVDLSDQAALEELMTDA
RP

Nucleotide

• Length: 249 bp

>AT61962 NZ_CP014989:c3125037-3124789 [Serinicoccus hydrothermalis]
GTGCGCACGACCATCCGGTTGCCCCAGGACCTCTACGACGAGGTGCGCGAGACGGCGCTCCGCGAGCGCAGGACCGTGAC
CTCACTCATCGAGGAGTCGCTGCGCGAGGCCCTGGCCTCACGGAGCCACCGGCGCCACGACGCGCCCTTCTCGCTCACGC
CGGTCGGCGGGGACGGCGGGCTCCGTCCGGGCGTCGACCTGAGCGACCAGGCCGCCCTGGAAGAGCTCATGACCGATGCT
CGCCCTTGA

Structures

Toxin

• AlphaFold DB: A0A1B1NFS6

Antitoxin

• AlphaFold DB: A0A1B1NFQ3